Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model

Abstract

Author's summary Although YKL-40 is associated with numerous other diseases, recent data suggest that inhibition of YKL-40 may be a new treatment strategy for cardiovascular disease (CVD). In light of these data, we examined the effect of diets containing deficient, adequate, and fortified vitamin D (VitD) on YKL-40 in an experimental hypercholesterolemic model. Our results reveal that VitD deficiency and supplementation, when evaluated together, reduce the level of YKL-40. We believe that our results will contribute to the knowledge between VitD and CVD.

Evaluation of Vitamin B12, Folic Acid, Ferritin and Vitamin D Levels in Obsessive Compulsive Disorder

“…For all these reasons, VitD may be associated with psychiatric disorders. [21][22][23][24] Iron is essential for life but too much iron is toxic. For this reason an iron storage protein is needed to regulate tissue and body iron homeostasis.…”

Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection

“…In this issue of the Korean Circulation Journal , Kocabas 7) performed an animal experiment and provided evidence that vitamin D supplementation effectively suppressed serum YKL-40 levels in a hypercholesterolemia rat model. First, the researchers found that blood levels of YKL-40 were increased in rats fed a high-cholesterol-rich diet compared to rats fed a normal diet.…”

“…The anti-inflammatory action of vitamin D is expected to contribute at least to some extent to its cardiovascular protective effect. In this regard, recent animal study has suggested that YKL-40, an inflammatory glycoprotein, is an important target of vitamin D. 7) Further studies are needed to determine whether vitamin D supplementation also lowers YKL-40 concentrations in human blood and whether the cardiovascular prognosis is affected by the YKL-40 concentrations. Recently, disappointing results have been published that vitamin D supplementation does not improve cardiovascular outcomes in humans.…”