Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection

Kim, Hack‐Lyoung

doi:10.4070/kcj.2023.0016

Korean Circ J

2023

DOI: 10.4070/kcj.2023.0016

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Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection

Hack‐Lyoung Kim

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2023

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Cited by 2 publications

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Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2

Manolis,

Melita

et al. 2023

CVP

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Cardiovascular disease (CVD) is a major cause of morbidity/mortality world-wide, hence preventive interventions are crucial. Observational data showing beneficial CV-effects of vitamin supplements, promoted by self-proclaimed experts, have led to ~50% of Americans using multivitamins; this practice has culminated into a multi-billion-dollar business. However, robust evidence is lacking, and certain vitamins might incur harm. This two-part review focuses on the attributes or concerns about specific vitamin consumption on CVD. The evidence for indiscriminate use of multivitamins indicates no consistent CVD benefit. Specific vitamins and/or combinations are suggested, but further supportive evidence is needed. Data presented in Part 1 indicated that folic acid and certain B-vitamins may decrease stroke, whereas niacin might raise mortality; beta-carotene mediates pro-oxidant effects, which may abate the benefits from other vitamins. In Part 2, data favor the anti-oxidant effects of vitamin C and the anti-atherogenic effects of vitamins C and E, but clinical evidence is inconsistent. Vitamin D may provide CV protection, but data are conflicting. Vitamin K appears neutral. Thus, there are favorable CV-effects of individual vitamins (C/D), but randomized/controlled data are lacking. An important caveat regards the potential toxicity of increased doses of fat-soluble vitamins (A/D/E/K). As emphasized in Part 1, vitamins might benefit subjects who are antioxidant-deficient or exposed to high levels of oxidative-stress (e.g., diabetics, smokers, and elderly), stressing the importance of targeting certain subgroups for optimal results. Finally, by promoting CV-healthy balanced-diets, we could acquire essential vitamins and nutrients and use supplements only for specific indications.

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Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2

Manolis,

Melita

et al. 2023

CVP

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Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Majid

Hassan

Hoque

et al. 2023

JCDD

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Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review aims to provide a thorough overview of the mechanisms underlying cardiac fibrosis, address the limitations of current treatment strategies, and specifically explore the potential of bioactive compounds as therapeutic interventions for the treatment and/or prevention of cardiac fibrosis.

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Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection

Cited by 2 publications

References 10 publications

Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2

Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

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