Effect of Vitamin C on Copper and Iron Status in Men and Guinea Pigs.

Pekiner, Bilgehan; Nebioğlu, Serpil

doi:10.3177/jnsv.40.401

Cited by 8 publications

(5 citation statements)

References 26 publications

(22 reference statements)

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“…) and serum iron (6 mmol l -1 ) after 1 month; however, levels were comparable to baseline after a second month of supplementation 128 . Lack of concurrent comparison groups weaken the results of both of these studies.…”

Section: Vitamin Cmentioning

confidence: 77%

“…Non-experimental studies support a modest effect of vitamin C. For example, a study among Indian vegetarians observed signi®cant increases in Hb (by 8%), serum iron (by 17%) and serum ferritin (by 12%) from baseline following receipt of 500 mg of vitamin C after lunch and dinner for 2 months 127 . Providing well-nourished Turkish subjects with vitamin C (2 g) daily was associated with rises in Hb concentration (11 g l -1 ) and serum iron (6 mmol l -1 ) after 1 month; however, levels were comparable to baseline after a second month of supplementation 128 . Lack of concurrent comparison groups weaken the results of both of these studies.…”

Section: Vitamin Cmentioning

confidence: 90%

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The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

263

208

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Objective: While iron de®ciency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B 12 , C and E, folic acid and ribo¯avin status have also been linked to its development and control. This paper provides a systematic review of vitamin supplementation trials relating to the control of nutritional anaemia. Methods: A MEDLINE search was used to ®nd reports of vitamin supplementation trials that reported changes in anaemia or iron status. Results: Vitamin A can improve haematological indicators and enhance the ef®cacy of iron supplementation. Both folate and vitamin B 12 can cure and prevent megaloblastic anaemia. Ribo¯avin enhances the haematological response to iron, and its de®ciency may account for a signi®cant proportion of anaemia in many populations. Vitamin C enhances the absorption of dietary iron, although population-based data showing its ef®cacy in reducing anaemia or iron de®ciency are lacking. Vitamin E supplementation given to preterm infants has not reduced the severity of the anaemia of prematurity. Vitamin B 6 effectively treats sideroblastic anaemia. Multivitamin supplementation may raise haemoglobin (Hb) concentration, but few studies have isolated the effect of multivitamins from iron on haematological status. Conclusions: In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis suf®ciently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages. Further research is needed to understand the roles of individual and combined vitamin de®ciencies on anaemia to design appropriate micronutrient interventions to prevent anaemia.

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Section: Vitamin Cmentioning

confidence: 77%

Section: Vitamin Cmentioning

confidence: 90%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

263

208

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“…Vitamin C in high level is a vigorous inhibitor of Cu absorption and/ or enzymes that depend on Cu results in iron utilization deficiency and can lead to iron toxicity (Pekiner & Nebioglu, 1994). Administration of VC supplementation reduces the risk of Cu toxicity when supplying adequate Cu amount reduces the risk of hypervitaminosis (Watts, 1989).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary copper nanoparticles and vitamin C supplementations on growth performance, immune response and stress resistance of red sea bream,Pagrus major

et al. 2017

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A 60-day feeding trial was conducted to determine the effects of copper nanoparticles (Cu-NPs) and vitamin C (VC) on red sea bream. Besides the control diet (D1), six diets were supplemented with Cu-NPs and VC [0/800 (D2), 0/1,000 (D3), 0/1,200 (D4), 2/800 (D5), 2/1,000 (D6) and 2/1,200 (D7) mg Cu-NPs/VC per kg]. Cu-NP was a significant factor on final weight (FBW), weight gain (WG) and specific growth rate (SGR), feed intake (FI), feed (FER) and protein efficiency ratios (PER), protein gain (PG) and protein retention (PR), body protein and lipid contents, protease (PA) and bactericidal activities (BA) and tolerance against stress (LT50%) (p < .05). In addition, BA and LT50% were significantly affected by either Cu-NPs or VC (p < .05). Fish fed Cu-NPs or/and VC-supplemented diets showed higher FBW, WG, SGR, PG, PR, FI, PA, LA and BA values when compared with the control group (p < .05). FER, PER and body lipid content were significantly enhanced in D4, D5, D6 and D7 groups; meanwhile, body protein and LT50% were significantly enhanced in D5, D6 and D7 groups when compared with D1 group (p < .05). In conclusion, dietary Cu-NPs or/and VC improved growth and health of red sea bream.

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“…Its interaction with the copper I1 (cupric) ion is well known, but the in vivo biological consequences of this interaction are less well understood. Previous studies have explored some aspects of this interaction in guinea-pigs (Hitier, 1976;Milne & Omaye, 1980;Smith & Bidlack, 1980;Kassouny et al 1985;DiSilvestro, 1986;Pekiner & Nebioglu, 1994); in rats (Van Campen & Gross, 1968;Johnson & Murphy, 1988;van den Berg et al 1994); in rabbits (Hunt & Carlton, 1965); in chicks (Starcher et al 1964;Carlton & Henderson, 1965;Hill & Starcher, 1965;DiSilvestro & Harris, 1981); in monkeys (Milne et al 1981) and in human subjects (Finley & Cerklewski, 1983;Jacob et al 1987;Milne et al 1988;Pekiner & Nebioglu, 1994). There have also been studies in cultured cells (Harris & Percival, 1991 .…”

mentioning

confidence: 99%

Vitamin C and copper interactions in guinea-pigs and a study of collagen cross-links

Tsuchiya

Bates

1997

Br J Nutr

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While it is clear from these studies that high concentrations or intakes of ascorbate can reduce tissue concentrations of Cu in a variety of species, there is a less clear consensus and uniformity with respect to possible functional effects of ascorbate overload on Cudependent processes in viva Several early studies on aortic rupture in chicks (Starcher et al. 1964;Carlton & Henderson, 1965;Hill & Starcher, 1965) obtained strong evidence for a gross failure of elastin cross-linking, attributed to reduced activity of the key enzyme, lysyl oxidase, in birds that were exposed simultaneously to excessive dietary ascorbate, and to low dietary Cu levels. Studies in mammalian species, however, have not reproduced such a dramatic effect. Nevertheless, in view of the potential importance of this interaction, for human subjects who choose to take daily megadoses of ascorbic acid, there is a need for further studies in relevant animal models such as the guinea-pig, which like humans has an absolute requirement for dietary ascorbate, as well as for Cu. The possibility that high levels of circulating vitamin C may increase the likelihood of Fe acting pro-oxidatively, and thereby influence outcome, has been illustrated by recent studies of human pre-term infants (Silvers et al. 1994;Powers et al. 1995). Deleterious effects of high ascorbate intakes may thus involve more than one transition metal.Another separate but related question arises from the need for better biochemical tests for suboptimum v. optimum status, with respect to those functionally-critical processes which are dependent on specific micronutrients. Collagen cross-linking is such a process. A severe lack of Cu can impair the activity of the Cu-dependent enzyme lysyl oxidase, responsible for the initiation of cross-linking (Farquharson et al. 1989;Robins, 1994). Impairment of cross-linking may then result in loss of tensile strength. Lack of ascorbic acid is well known to affect the hydroxylation of collagen lysyl residues (Kivirikko & Myllyla, 1982;Yeowell et al. 1995), and this could, in theory, alter the pattern of collagen cross-links, by altering the ratio of deoxypyridinoline (derived from lysine) to pyridinoline (derived from hydroxylysine) (Robins, 1994).The dual purpose of the present study was: first to re-examine the interactions of ascorbate and Cu, by dietary modulation in young guinea-pigs, and second, to test the hypothesis that Cu and/or ascorbate status might alter the ratio of deoxypyridinoline collagen-derived cross-links in bone and in urine. MATERIALS AND METHODS Animals and dietsThe purified guinea-pig diet contained the following components (g/kg): sucrose 331, maize starch 50, ovalbumin 300, cellulose powder 150, maize oil 73, potassium acetate 25, choline chloride 2, magnesium oxide 5 , inositol2, salt mixture 60, vitamins (see later). The salt mixture was based on that of Greenfield et al. (1969), except that the CuS04 therein was omitted. It contained (g/kg): CaC03 205, CaHP04 325, Na2HP04 185, KC1 205, MgS04 70, MnS04 4-5, Fe-citrate...

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Effect of Vitamin C on Copper and Iron Status in Men and Guinea Pigs.

Cited by 8 publications

References 26 publications

The role of vitamins in the prevention and control of anaemia

The role of vitamins in the prevention and control of anaemia

Effects of dietary copper nanoparticles and vitamin C supplementations on growth performance, immune response and stress resistance of red sea bream,Pagrus major

Vitamin C and copper interactions in guinea-pigs and a study of collagen cross-links

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