Effect of vitamin A dietary intake on in vitro and in vivo activation of aflatoxin B1

Decoudu, S.; Cassand, Pierrette; Daubèze, M.; Frayssinet, C; Narbonne, Jean‐François

doi:10.1016/0027-5107(92)90209-k

Cited by 27 publications

(9 citation statements)

References 38 publications

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“…Similar results were found studying woodchuck hepatocytes (Yu et al, 1994). The information indicated above suggested to researchers that the main action of vitamin A (as well as of other vitamins) was on the initiating step of AFB1 carcinogenesis, yet there still remained studies to be done so as to clarify the issue on the preventive biochemical action of the vitamin Decoudu et al, 1992). The antigenotoxic and antitoxic potential of vitamin A was determined in experimental mice.…”

Section: Vitaminssupporting

confidence: 68%

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Madrigal-Bujaidar¹,

Madrigal-Santillán²,

Álvarez-González³

et al. 2011

Aflatoxins - Detection, Measurement and Control

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Section: Vitaminssupporting

confidence: 68%

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Madrigal-Bujaidar¹,

Madrigal-Santillán²,

Álvarez-González³

et al. 2011

Aflatoxins - Detection, Measurement and Control

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“…Previous studies on the protective effects of antioxidants, such as ethoxyquin, selenium, b-carotene and vitamin A, against the cytotoxicity and genotoxicity of AFB 1 were mostly focused on the metabolism and detoxification of AFB 1 or the formation of AFB 1 -DNA adducts. [56,57] Shen et al [58] reported that AFB 1 causes lipid peroxidation in rat liver and pretreatment with vitamin E, selenium, or deferoxamine, an iron chelator, significantly inhibited lipid peroxidation as well as liver cell damage. There is no enough data on the protective role of AA against the toxicity of AFB 1 , therefore our study was aimed to investigate the role of AA as an antioxidant against the oxidative stress of AFB 1 .…”

Section: Ascorbic Acidmentioning

confidence: 98%

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Yousef

Salem

Kamel³

et al. 2003

Journal of Environmental Science and Health, Part B

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This study was undertaken to evaluate the effectiveness of L-ascorbic acid (AA) in alleviating the toxicity of aflatoxin B1 (AFB1) in male New-Zealand white rabbits. Five rabbits (6 months of age and mean body weight 3.12 kg) per group were assigned to 1 of 6 treatment groups: 0 mg AA and 0 mg AFB1/kg BW (control); 20 mg AA/kg BW; 15 microg AFB1/kg BW; 15 microg AFB1 plus 20 mg AA/kg BW; 30 pg AFB1/kg BW; 30 pg AFB1 plus 20 mg AA/kg BW. Rabbits were orally administered their respective doses every other day for 9 weeks, followed by a 9-week recovery period where all drugs were withdrawn. Evaluations were made for hemato-biochemical parameters and enzymatic activities. Results showed that AFB1 significantly (p< 0.05) decreased hemoglobin (Hb), total erythrocytic count (TEC) and packed cell volume (PCV), in a dose-dependent manner, and these effects were continued during the recovery period. Ascorbic acid caused an increase in these parameters, and alleviated the negative effect of AFB1 during the treatment period. Additionally, serum concentrations of total protein, albumin and glucose were significantly (P < 0.05) declined by treatment with the high dose of aflatoxin and these effects were continued during the recovery period. Ascorbic acid caused non-significant increases in these parameters and alleviated the harmful effect of AFB1. On the other hand, aflatoxin treatment caused significant increases (P < 0.05) in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AlP) during the treatment period in a dose dependent manner, and this effect was continued during the recovery period, especially with the high dose. Also, treatment with the high dose of aflatoxin caused significant increases (P<0.05) in cholesterol and total bilirubin. Ascorbic acid caused significant decreases in these parameters and alleviated the harmful effects of AFB1. Whereas, Total leukocyte count (TLC), urea and creatinine were not significantly affected by aflatoxin-treatment. Generally, it is interesting feature that the treatment with AA alone had no negative effects on most of the previous parameters. Also, the presence of AA could diminished the adverse effects of AFB1 on most of hematological and biochemical values, and enzymatic activities in rabbits.

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“…Selenium has antimutagenic and anticarcinogenic activity. Previous studies on the protective effects of antioxidants such as selenium and vitamin A against the cytotoxicity and genotoxicity of AFB 1 mostly focused on the metabolism and detoxification of AFB 1 or the formation of AFB 1 -DNA adduct (Chen et al, 1982b;Mandel et al, 1987;Decoudu et al, 1992). It was also suggested that the protective effect of selenium could be mediated through a cellular mechanism related to glutathione detoxification pathways (Shen et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

Uysal

Ağar

2005

Braz. arch. biol. technol.

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Effect of vitamin A dietary intake on in vitro and in vivo activation of aflatoxin B1

Cited by 27 publications

References 38 publications

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

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Effect of vitamin A dietary intake on in vitro and in vivo activation of aflatoxin B1

Cited by 27 publications

References 38 publications

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B1

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

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Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁