Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

Uysal, Handan; Ağar, Güleray

doi:10.1590/s1516-89132005000200009

Cited by 12 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is generally accepted that this element is a crucial component of several vital metabolic pathways, the antioxidant defense system and the functioning of the immune system [ 51 ]. A growing number of evidence revealed that Se has emerged as an important element in the dietary prevention of various toxic agents [ 52 , 53 ]. Se could inhibit gross and histopathological lesions in most of the organs induced by AFB 1 [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

et al. 2017

View full text Add to dashboard Cite

Aflatoxin B1 (AFB1), the most common mycotoxin in human food and animal feed, produces hepatotoxic, genotoxic and immunosuppressive effects in multiple species. Selenium (Se) has emerged as an important element in the dietary prevention of various toxic agents. The present study was designed to scrutinize the protective effects of sodium selenite on the histological lesions and suppression of mucosal humoral response in the cecal tonsil generated by AFB1. A total of 156 one-day-old broilers were divided into four groups and fed on basal diet (control group), 0.6 mg/kg AFB1 (AFB1 group), 0.4 mg/kg Se supplement (+Se group), and 0.6 mg/kg AFB1 + 0.4 mg/kg Se supplement (AFB1+Se group) respectively for 21 days. Our results showed that 0.4 mg/kg Se supplement in broiler's diets could improve the AFB1-induced histological lesions in the cecal tonsils including the depletion of lymphocytes in the lymphatic nodules as well as the shedding of microvilli in the absorptive cells. Moreover, Se could restore the decreased number of IgA+ cells and expression levels of pIgR, IgA, IgG, and IgM mRNA induced by AFB1 to be close to those in the control group. These results demonstrated that 0.4 mg/kg supplemented dietary Se in the form of sodium selenite could protect the cecal tonsils from the histological lesions and suppression of the mucosal humoral response provoked by 0.6 mg/kg AFB1. Our study may provide new experimental evidences for better understanding of AFB1-induced damage of mucosal immunity and protective effect of Se against this toxin.

show abstract

Section: Discussionmentioning

confidence: 99%

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Selenium might enhance the conjugation of aflatoxins by increasing excretion of the aflatoxins and by preventing the formation of AFB1-DNA adducts. The protective effect of selenium is mediated through a cellular mechanism related to glutathione detoxification pathways [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Functional role of selenium-fortified yogurt against aflatoxin-contaminated nuts in rats

Alsuhaibani

2018

Agric & Food Secur

View full text Add to dashboard Cite

Background: Aflaxions are a group of chemically toxic fungal metabolites produced by species of the genus Aspergillus. Nuts can be contaminated by fungi, resulting in the production of mycotoxins. The present study was performed to investigate the ability of selenium-fortified yogurt to counteract the adverse effects of consuming 3% experimental nuts (pistachios, cashews, walnuts, almonds and hazelnuts) contaminated with aflatoxins in experimental rats. First, the total aflatoxins concentrations were estimated in fresh nuts, and in nuts after 6 months of storage, and seleniumfortified yogurt was prepared. Rats were classified into a negative control group (fed a standard diet with a 3% mixture of fresh safe nuts), a positive control group (fed a standard diet with a 3% mixture of nuts contaminated with aflatoxins after storage at 25 °C for 6 months) and treated groups that fed on pistachios with selenium-fortified yogurt, cashews with selenium-fortified yogurt, walnuts with yogurt fortified with selenium, almonds with selenium-fortified yogurt and hazelnuts with selenium-fortified yogurt (fed a standard diet with 3% individual nuts contaminated with aflatoxins and 160 ml/kg body weight of selenium-fortified yogurt daily through a stomach tube). Results: The negative effects of aflatoxins on weight gain and food intake were reversed by selenium-fortified yogurt. This yogurt also led to a significant decrease in serum cholesterol, TG, LDLc, VLDLc, total lipids, phospholipids, glucose and atherogenic indexes (CHO/HDLc and LDLc/HDLc) and an increase in serum HDLc, haemoglobin, PCV, liver TG and glycogen at p < 0.05. In addition, the study showed a significant decrease in liver cholesterol and total lipids compared to the positive control rat group, which consumed 3% mixed nuts contaminated with aflatoxins and simultaneously restored these parameters to be close to those in the control group. The results were corroborated by histopathological examination of the liver and kidneys. Conclusions: The most prominent conclusion is that selenium-fortified yogurt reduces side effects from consumption of nuts contaminated with aflatoxins. It is recommended to consume functional selenium-fortified yoghurt for its nutritional values and for alleviating the harmful effect of aflatoxins in nuts.

show abstract

“…Em vários carcinomas, principalmente o hepático, é característico este tipo de alteração (PINHEIRO, 2004, FERREIRA et al, 2006. (CALONI et al, 2006;UYSAL et al, 2005;MASSEY et al, 1995;McLEAN;DUTTON, 1995;FORRESTER et al, 1990).…”

Section: Aflatoxinasunclassified

“…Todavia, os padrões de biotransformação da AFB 1 possuem uma variação muito grande inter ou intra-espécie, o que explicaria os diferentes graus de suscetibilidade à AFB 1 (UYSAL et al, 2005;LOPES et al, 2005;BUSBY;WOGAN, 1984).…”

Section: Aflatoxinasunclassified

“…Todavia, vários autores vêm demostrando que os padrões de biotransformação da AFB 1 possuem uma variação muito grande entre as espécies, o que explicaria os diferentes graus de suscetibilidade à AFB 1. Algumas espécies são sensíveis mesmo em doses baixas (BUSBY; WOGAN, 1984;UYSAL et al, 2005;LOPES et al, 2005;SANTACROCE et al, 2007;KHALIL, 2009;MOHAMED et al, 2017).…”

Section: Aflatoxinas No Fígado E Músculo De Peixes Redondosunclassified

See 1 more Smart Citation

Avaliação da micobiota da ração e da ocorrência de resíduos de afloxitonas nos tecidos de peixes redondos

Gomes¹

View full text Add to dashboard Cite

AGRADECIMENTOSAgradeço a Deus primeiramente, pois, Ele é o sentido de tudo, obrigado pelas Graças concedidas, pela saúde, força e fé ao longo desta jornada.Agradeço a meus pais, mesmo às vezes não compreendendo não deixaram de dar seu apoio, em especial, ao meu namorado Alan que moveria montanhas para eu realizar todos meus sonhos e projetos, a minha grande amiga Bruna, por sempre me motivar a crescer como pessoa e nunca me deixar desistir quando surgem as adversidades. Vocês são mais que especiais, amo vocês! Agradeço a minha orientadora Andrezza pela oportunidade da realização do mestrado, por todo conhecimento que adquiri através da pesquisa, da companhia nos congressos e também nos city tour. Muito obrigada! Agradeço a Sílvia por toda ajuda ao longo do projeto e pela paciência, a Maria Fernanda pela amizade e pelos quilômetros rodados nas coletas e a Milena pela parceria no laboratório, nos congressos, viagens e cervejas! Sou muito grata a vocês! Agradeço a toda equipe do Laboratório Multiusuário de Microbiologia e Higiene Zootécnica pela convivência, apoio e companhia no café:

show abstract

Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

Abstract: ABSTRACT

Cited by 12 publications

References 26 publications

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

Functional role of selenium-fortified yogurt against aflatoxin-contaminated nuts in rats

Avaliação da micobiota da ração e da ocorrência de resíduos de afloxitonas nos tecidos de peixes redondos

Contact Info

Product

Resources

About