Effect of visible light on some cellular and immune parameters

Kubasova, Tamara; Horváth, Márta; Kocsis, Krisztián; Fenyő, Márta

doi:10.1038/icb.1995.39

Cited by 40 publications

(32 citation statements)

References 15 publications

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“…The effect of LPL and DL on the blast transformation of purified human T lymphocytes was investigated in vitro. LPL had a pronounced effect, whilst DL had no effect at all, producing results similar to those shown by the untreated control cells (Kubasova et al 1995).…”

supporting

confidence: 63%

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Effect of Polarized Light Treatment on Milk Production and Milk Somatic Cell Count of Cows

Fenyő¹,

Szita

Bartyik³

et al. 2008

Acta Vet. Brno

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Fenyő M., G. Szita, J. Bartyik, J. Dóra, S. Bernáth: Effect of Polarized Light Treatment on Milk Production and Milk Somatic Cell Count of Cows. Acta Vet. Brno 2007, 77: 225-229. Treatment with linearly polarized light (LPL) is a widely used and recognized therapeutic method in human medicine for healing wounds, ulcers and a variety of other dermatological problems. Polarized light mobilizes the inadequately functioning defence mechanisms of the human body. The aim of the present experiment was to investigate the effect of LPL treatment on the udder of milking cows.Before the start of treatment, there was no significant difference between cows to be treated with LPL and the control cows in mean somatic cell counts (SCC) of milk samples taken separately by udder quarter and in the mean milk yield. The LPL treatment lasted for 20 min and was performed twice a day over a period of one month. Before treatment, the mean SCC of milk was 3.47 × 10 5

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supporting

confidence: 63%

“…The spleen of mice previously inoculated with Ehrlich ascites tumor was treated with LPL and DL. Reduction of the mitotic index was observed in LPL-treated mice, and there was no effect in the case of DL (Kubasova et al 1995).…”

mentioning

confidence: 89%

Effect of Polarized Light Treatment on Milk Production and Milk Somatic Cell Count of Cows

Fenyő¹,

Szita

Bartyik³

et al. 2008

Acta Vet. Brno

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“…Considerable work has been directed towards determining the biological effects of He-Ne laser that would account for its observed wound healing and pain relief effects [1,25]. Wound healing is one of the most studied aspects of low-energy lasers [6].…”

Section: Discussionmentioning

confidence: 99%

Low-energy He/Ne laser in the prevention of radiation-induced mucositis

Bensadoun

Franquin

Ciais

et al. 1999

Support Care Cancer

208

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Use of the low-energy helium-neon laser (LEL) appears to be a simple atraumatic technique for the prevention and treatment of mucositis of various origins. Preliminary findings, and significant results obtained for chemotherapy-induced mucositis in a previous phase III study, prompted a randomized multicenter double-blind trial to evaluate LEL in the prevention of acute radiation-induced stomatitis. Irradiation by LEL corresponds to local application of a high-photon-density monochromatic light source. Activation of epithelial healing for LEL-treated surfaces, the most commonly recognized effect, has been confirmed by numerous in vitro studies. The mechanism of action at a molecular and enzymatic level is presently being studied. From September 1994 to March 1998, 30 patients were randomized. Technical specification: 60 mW (25 mW at Reims, 1 patient), He-Ne, wavelength 632.8 nm. The trial was open to patients with carcinoma of the oropharynx, hypopharynx and oral cavity, treated by radiotherapy alone (65 Gy at a rate of 2 Gy/fraction, 5 fractions per week) without prior surgery or concomitant chemotherapy. The malignant tumor had to be located outside the tested laser application areas (9 points): posterior third of the internal surfaces of the cheeks, soft palate and anterior tonsillar pillars. Patients were randomized to LEL or placebo light treatment, starting on the first day of radiotherapy and before each session. The treatment time (t) for each application point was given by the equation : t(s)= energy (J/cm2) x surface (cm2)/Power (W). Objective assessment of the degree of mucositis was recorded weekly by a physician blinded to the type of treatment, using the WHO scale for grading of mucositis and a segmented visual analogue scale for pain evaluation. Protocol feasibility and compliance were excellent. Grade 3 mucositis occured with a frequency of 35.2% without LEL and of 7.6% with LEL (P<0.01). The frequency of "severe pain" (grade 3) was 23.8% without LEL, falling to 1.9% with LEL (P<0.05). Pain relief was significantly reduced throughout the treatment period (weeks 2-7). LEL therapy is capable of reducing the severity and duration of oral mucositis associated with radiation therapy. In addition, there is a tremendous potential for using LEL in combined treatment protocols utilizing concomitant chemotherapy and radiotherapy.

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“…The exposure to light of immune-competent cells leads to changes in their functional condition and, consequently, to the stimulation of the immune system, manifesting itself in the increased defense capacity of an organism [17]. VIS and infrared light regulate human humoral immunity [18], manage allergic rhinitis [19], increase antitumor immunity [20] and skin-homing T cells [21], and stimulate DNA synthesis in human peripheral blood lymphocytes [22].…”

Section: Introductionmentioning

confidence: 99%

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

Choi

Lim

Lee

et al. 2012

Neuroimmunomodulation

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Objective: The phototherapeutic effects of low level infrared laser irradiation (808 nm) on brain neuronal cell protection after stroke have been presented recently. We previously reported that 710-nm wavelength visible light (VIS) increases total lymphocyte counts in vivo, especially CD4⁺ T lymphocytes. In this study, we investigated the effects of 710-nm VIS irradiation on neuronal protection and recovery correlating with cellular immunity in stroke rats. Methods: Rats were subjected to 90-min middle cerebral artery occlusion (MCAO) followed by reperfusion and were divided into two groups: irradiation and no irradiation. The irradiation group had been exposed to 710-nm VIS for 3 weeks after MCAO establishment or sham operation. The helper T cell (CD4⁺) count in the whole blood and infarct volume were measured. Messenger RNA expression levels of IL-4 and IL-10 in peripheral blood mononuclear cells were measured, a histologic study including microglia activation and regulatory T (Treg) cell markers, neurological severity scoring and a parallel bar walking test were all performed. Results: CD4⁺ cell count was reduced after MCAO but was significantly increased by 710-nm VIS irradiation. The infarct sizes were decreased in the MCAO + irradiation group compared with the MCAO control group. IL-10 mRNA expression and the immunoreactivity of Treg cells were increased in the MCAO + irradiation group compared with the MCAO control group. Increased microglia activation after MCAO was reduced by 710-nm VIS irradiation. The irradiation group also showed improved neurological severity score levels and step fault scores after MCAO. Conclusions: Our data suggest that 710-nm VIS irradiation may activate cellular immunity, reduce brain infarction and ultimately induce functional recovery in a stroke animal model.

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Effect of visible light on some cellular and immune parameters

Cited by 40 publications

References 15 publications

Effect of Polarized Light Treatment on Milk Production and Milk Somatic Cell Count of Cows

Effect of Polarized Light Treatment on Milk Production and Milk Somatic Cell Count of Cows

Low-energy He/Ne laser in the prevention of radiation-induced mucositis

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

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