Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: Role of Hsp70 protein

Mechanism of dihydroartemisinin-induced apoptosis in prostate cancer PC3 cells: An iTRAQ-based proteomic analysis

“…In the present study, DHA significantly decreased HSP70 expression and induced apoptosis in PC3 cells. Although the mechanism of apoptosis induced by DHA is poorly understood, several lines of evidence have shown inhibition of HSP70 expression results in apoptosis of cancer cells, and/or sensitizes cells to anticancer therapy in prostate cancer lines PC3, PC3M, DU145, LNCaP, JCA-1, and 22RV1 [87][88][89][90][91][92][93][94][95]. Our protein interaction network analysis suggests that HSP70 should function as both a chaperone and a modulator of cell signaling to participate in several biological processes in response to the cytotoxicity of DHA in PC3 cells.…”

Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro

“…Protolichesterinic acid was able to induce apoptosis through a caspase-dependent pathway in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells [9] and in HeLa cells [10]. In in vitro assays, protolichesterinic acid showed inhibitory action against 5-lipoxygenase from porcine leucocytes [11], platelet-type 12-lipoxygenase [12], human DNA ligase I [13] and DNA polymerase of HIV-1 reverse transcriptase [14].…”

“…The lichen compound (+)-protolichesterinic acid, an aliphatic a-methylene butyrolactone, showed antiproliferative activity on mitogen-stimulated lymphocytes and on several human cancer cell lines [7][8][9][10], but its mechanism of action is not yet fully elucidated. Protolichesterinic acid was able to induce apoptosis through a caspase-dependent pathway in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells [9] and in HeLa cells [10].…”

Genotoxic, cytotoxic, and apoptotic effects of crude extract of Usnea filipendula Stirt. in vitro

“…There are several studies reporting that lichen or lichen compounds resulted in apoptosis in different types of cancer cell lines (Mitrović et al, 2011;Russo et al, 2012;Singh et al, 2013). In our study, M30 levels were significantly increased in MCF-7 cells after the treatment with UFE.…”