Effect of ventricle motion on the dynamic behaviour of chorded mitral valves

Watton, Paul N.; Luo, Xiaoyu; Yin, Mingyan; Bernacca, G M; Wheatley, D. J.

doi:10.1016/j.jfluidstructs.2007.06.004

Cited by 32 publications

(50 citation statements)

References 40 publications

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“…The fluid-structure interaction between mitral leaflets and the surrounding blood was taken into account by Einstein et al (2005a) and Watton et al (2007Watton et al ( , 2008. The two groups modelled the fluid-structure coupling through different algorithms:…”

Section: (D ) Valve-blood Interactionmentioning

confidence: 99%

“…This second clinical issue was also the subject of the study of Dal Pan et al (2005). Very recently, a sixth research group has used fluid-structure interaction modelling as a tool to predict the performance of bioprosthetic mitral valves (Watton et al 2007(Watton et al , 2008. Although the focus of their studies is on prostheses with different morphological and mechanical properties when compared with the natural human valve, their modelling strategy could be adopted in analysis of the mitral valve.…”

Section: Introductionmentioning

confidence: 99%

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Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios

Votta

Caiani

Veronesi

et al. 2008

Phil. Trans. R. Soc. A.

107

108

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In the current scientific literature, particular attention is dedicated to the study of the mitral valve and to comprehension of the mechanisms that lead to its normal function, as well as those that trigger possible pathological conditions. One of the adopted approaches consists of computational modelling, which allows quantitative analysis of the mechanical behaviour of the valve by means of continuum mechanics theory and numerical techniques. However, none of the currently available models realistically accounts for all of the aspects that characterize the function of the mitral valve. Here, a new computational model of the mitral valve has been developed from in vivo data, as a first step towards the development of patient-specific models for the evaluation of annuloplasty procedures. A structural finiteelement model of the mitral valve has been developed to account for all of the main valvular substructures. In particular, it includes the real geometry and the movement of the annulus and papillary muscles, reconstructed from four-dimensional ultrasound data from a healthy human subject, and a realistic description of the complex mechanical properties of mitral tissues. Preliminary simulations allowed mitral valve closure to be realistically mimicked and the role of annulus and papillary muscle dynamics to be quantified.

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Section: (D ) Valve-blood Interactionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios

Votta

Caiani

Veronesi

et al. 2008

Phil. Trans. R. Soc. A.

107

108

View full text Add to dashboard Cite

show abstract

“…Let V * (t) be the volume of blood in the ventricle during the heart cycle, with a maximum V 274 V. Meschini, M. D. de Tullio, G. Querzoli and R. Verzicco & Tonti (2010) and Querzoli et al (2010) have underlined the strong influence the mitral valve has on the diastolic flow structure, and Einstein et al (2005), Wattona et al (2008) and Griffith et al (2009) have focused on the dynamics of mitral valve leaflets. Moreover, McQueen & Peskin (2000) and Mihalef et al (2011) have studied the effect of combining realistic intra-ventricular flow with a physiological mitral valve using patient-specific models without fluid-structure interaction.…”

mentioning

confidence: 99%

Flow structure in healthy and pathological left ventricles with natural and prosthetic mitral valves

Meschini

Tullio²,

Querzoli

et al. 2017

J. Fluid Mech.

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In this paper, the structure and the dynamics of the flow in the left heart ventricle are studied for different pumping efficiencies and mitral valve types (natural, biological and mechanical prosthetic). The problem is investigated by direct numerical simulation of the Navier-Stokes equations, two-way coupled with a structural solver for the ventricle and mitral valve dynamics. The whole solver is preliminarily validated by comparisons with ad hoc experiments. It is found that the system works in a highly synergistic way and the left ventricular flow is heavily affected by the specific type of mitral valve, with effects that are more pronounced for ventricles with reduced pumping efficiency. When the ventricle ejection fraction (ratio of the ejected fluid volume to maximum ventricle volume over the cycle) is within the physiological range (50 %-70 %), regardless of the mitral valve geometry, the mitral jet sweeps the inner ventricle surface up to the apex, thus preventing undesired flow stagnation. In contrast, for pathological ejection fractions ( 40 %), the flow disturbances introduced by the bileaflet mechanical valve reduce the penetration capability of the mitral jet and weaken the recirculation in the ventricular apex. Although in clinical practice the fatality rates in the five-year follow-ups for mechanical and biological mitral valve replacements are essentially the same, a breakdown of the deaths shows that the causes are very different for the two classes of prostheses and the present findings are consistent with the clinical data. This might have important clinical implications for the choice of prosthetic device in patients needing mitral valve replacement.

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“…Over the last few years there have been a number of FSI valvular models using the immersed boundary (IB) approach [6,7,13,18]. However, none of these MV models included the effect of the LV motion, hence the flow field is not physiological.…”

Section: Introductionmentioning

confidence: 99%

Fluid-Structure Interaction Model of Human Mitral Valve within Left Ventricle

Gao

et al. 2015

Functional Imaging and Modeling of the Heart

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Abstract. We present an integrated model of mitral valve coupled with the left ventricle. The model is derived from clinical images and takes into account of the important valvular features, left ventricle contraction, nonlinear soft tissue mechanics, fluid structure interaction, and the MV-LV interaction. This model is compared with a corresponding mitral-tube model, and differences in the results are discussed. Although the model is a step closer towards simulating physiological realistic situation, further work is required to ensure that the highly complex valvular-ventricular interaction, and the fluid-structure interaction, can be reliably represented.

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Effect of ventricle motion on the dynamic behaviour of chorded mitral valves

Cited by 32 publications

References 40 publications

Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios

Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios

Flow structure in healthy and pathological left ventricles with natural and prosthetic mitral valves

Fluid-Structure Interaction Model of Human Mitral Valve within Left Ventricle

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