Effect of vehicle on intrauterine absorption of gentamicin in cattle

Aminoglycoside residues in food of animal origin

“…14,15 Intrauterine administration-Assigning appropriate WDIs is problematic after extralabel intrauterine treatment in food-producing animals because a variety of factors (eg, hormonal status, degree of uterine involution, and drug vehicle) may influence drug absorp-tion into the systemic circulation. 16,17 For intrauterine administration of gentamicin doses of 0.25 to 2.5 g, systemic bioavailability of 30% to 80% has been reported. 16,18,19 Blood and urine concentrations in those experiments suggest the presence of tissue residues, which is consistent with a report of gentamicin kidney residues detected 20 to 30 days after intrauterine administration of only 200 mg. 20 In 2 studies, 12,19 gentamicin milk residues were detected after intrauterine administration for up to 48 hours.…”

“…16,17 For intrauterine administration of gentamicin doses of 0.25 to 2.5 g, systemic bioavailability of 30% to 80% has been reported. 16,18,19 Blood and urine concentrations in those experiments suggest the presence of tissue residues, which is consistent with a report of gentamicin kidney residues detected 20 to 30 days after intrauterine administration of only 200 mg. 20 In 2 studies, 12,19 gentamicin milk residues were detected after intrauterine administration for up to 48 hours.…”