Blood kinetics of sulfamonomethoxine and oxytetracycline following intrauterine spray injection in dairy cows

Girardi, C.; Farca, Anna Maria; Dacasto, Mauro; Ferrero, Elisabetta; Eandi, Mario

doi:10.1016/1043-6618(90)90703-g

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…In the present study, the time needed for OTC to reach peak blood concentrations ( t max 11.71±4.15 h) was longer than that reported by other authors; in particular: 2–4 h (Bretzlaff et al, 1983), 6–8 h (Righter et al , 1975), and 8 h (Girardi et al ., 1990a). This observation may be partially explained by the time the formulation takes to dissolve.…”

Section: Discussioncontrasting

confidence: 56%

“…Girardi et al (1990a) observed that OTC is not well absorbed in cows affected by a mild metritis and treated by the intrauterine route with doses of 6–6.6 mg/kg in a spray formulation, as emphasized by the AUC value (12.94±4.98 μg/mL per h). This is also supported by Bretzlaff et al (1983), who observed that, following intrauterine infusion of 5.5 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 97%

“…In fact, unlike the formulations used in the above mentioned studies (spray or solution) in which the antibiotic is readily available for absorption, when administered as a solid form (pessaries), the active ingredient must first be released from the excipients. In cows treated with similar dosages of OTC in a spray formulation (Girardi et al ., 1990a), serum concentrations were lower than the detection threshold as early as 48th hour after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of the results obtained, it is possible to affirm that in healthy cows, following treatment with solid formulations in the early post partum phase, OTC is poorly and slowly absorbed from the uterus. This may also depend on the limited endoperitoneal absorption through the uterine tubes of this formulation compared to that of liquid and spray formulations (Girardi et al ., 1990a).…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics and residual behaviour in milk of oxytetracycline in cows following administration of uterine pessaries

Roncada¹,

Ermini²,

Schleuning³

et al. 2000

Vet Pharm & Therapeutics

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residual behaviour in milk of oxytetracycline in cows following administration of uterine pessaries. J. vet. Pharmacol. Therap. 23, 281 -285.The plasma kinetics and residual depletion in milk of cows treated by the intrauterine route with pessaries containing oxytetracycline (OTC) were evaluated. The antibiotic was administered to five healthy Friesian cows at a dosage of 3g/head in the early post partum phase. Blood samples were collected before and at different time intervals (3, 6, 12, 24, 48, 72, 84, and 96 h) after treatment. Milk was drawn before treatment and at 12-h intervals for 4 consecutive days. Samples were analysed by a high-performance liquid chromatography method and the pharmacokinetic parameters were processed using the minimum Akaike information criterion estimation (MAICE) test. The mean values obtained indicated a relatively low area under the concentration time curve (25.19 912.61 mg/mg per h) and maximum plasma concentration (C max ) (0.549 9 0.278 mg/mL) with delayed time to C max (11.719 4.15 h) and elimination half-life (21.9694.42 h). A similar pattern could be shown for milk, in which measurable residual levels are found in two out of five animals until the 72nd hour after treatment. Data obtained demonstrate that OTC administered as a solid form is poorly and slowly absorbed from the uterus of cows.(Paper

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacokinetics and residual behaviour in milk of oxytetracycline in cows following administration of uterine pessaries

Roncada¹,

Ermini²,

Schleuning³

et al. 2000

Vet Pharm & Therapeutics

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show abstract

“…In the present study, the first detectable level of CTC in the serum was recorded within the first hour of the treatment, whereas in dairy cattle, tetracycline cannot be recovered from serum 24 hours after intrauterine administration [31]. The quick access of the antibiotic to the serum reported in this study may be attributed to the rapid uterine involution in camelidae [32].…”

Section: Discussionmentioning

confidence: 65%