Effect of Various Surface Treatments on Wettability and Morphological Properties of Titanium Oxide Thin Films

Kuźmicz-Mirosław, Ewelina; Kuśmierz, Marcin; Terpiłowski, Konrad; Śmietana, Mateusz; Barczak, Mariusz; Staniszewska, Magdalena

doi:10.3390/ma15124113

Cited by 3 publications

(1 citation statement)

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“…However, nonadhesive GelMA hydrogels form a local coating layer on the surface of titanium implants. Therefore, it was attempted to increase the adhesion of the ginger (fraction) -loaded GelMA hydrogel to the surface by improving the wettability of the titanium surface [ 15 , 16 , 17 ] and to induce the formation of a uniform coating layer.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants

et al. 2022

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The gingerols and shogaols derived from ginger have excellent antibacterial properties against oral bacteria. However, some researchers have noted their dose-dependent potential toxicity. The aim of this study was to enhance the biofunctionality and biocompatibility of the application of ginger to dental titanium screws. To increase the amount of coating of the n-hexane-fractionated ginger on the titanium surface and to control its release, ginger was loaded in different concentrations in a photo-crosslinkable GelMA hydrogel. To improve coating stability of the ginger hydrogel (GH), the wettability of the surface was modified by pre-calcification (TNC), then GH was applied on the surface. As a result, the ginger fraction, with a high content of phenolic compounds, was effective in the inhibition of the growth of S. mutans and P. gingivalis. The GH slowly released the main compounds of ginger and showed excellent antibacterial effects with the concentration. Although bone regeneration was slightly reduced with the ginger-loading concentration due to the increased contents of polyphenolic compounds, it was strongly supplemented through the promotion of osteosis formation by the hydrogel and TNC coating. Finally, we proved the biosafety and superior biofunctionalities the GH−TNC coating on a Ti implant. However, it is recommended to use an appropriate concentration, because an excessive concentration of ginger may affect the improved biocompatibility in clinical applications.

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Section: Introductionmentioning

confidence: 99%