Effect of various stabilizers on the stability of lansoprazole nanosuspension prepared using high shear homogenization: Preliminary investigation

Abstract

The purpose of the current research work was to prepare a nanosuspension of the model drug lansoprazole (LSP) and investigate the effect of various stabilizers on the stability of the nanosuspension prepared using the high shear homogenization technique. In this study, polymeric stabilizers like polyvinylpyrrolidone K-30, polyvinylpyrrolidone K-90, polyvinyl alcohol, sodium alginate, and hydroxypropyl methylcellulose E15 and surfactants like sodium lauryl sulfate and Tween 80 were explored. The prepared nanosuspensions were evaluated for particle size distribution (PSD), polydispersity index (PI), zeta potential, and drug loading. Saturation solubility and in-vitro dissolution studies of optimized nanosuspension and coarse LSP powder were also carried out to determine the extent of solubility enhancement. PSD and zeta potential revealed that all the stabilizers when used alone could not significantly reduce the particle size and stabilize the colloidal dispersion. However, a combination of polymeric stabilizer and surfactant showed significant particle size reduction with an average particle size of 428.5 nm, PI 0.363, and a stable zeta potential value of −25.8 mV. Therefore, it can be concluded that LSP nanosuspension prepared by the high shear homogenization technique can be effectively stabilized by a combination of stabilizers.

Physical stability and dissolution of ketoprofen nanosuspension formulation: Polyvinylpyrrolidone and Tween 80 as stabilizers

“…Furthermore, the particle size distribution in the formulation was evaluated as PI, which gave a degree of PSD. The PI is an important evaluation parameter that controls the physical stability of nanosuspensions and should be kept as low as possible to achieve the long-term stability of a nanosuspension (Ubgade et al 2021). The present study indicated that the PIs of the produced ketoprofen nanosuspensions after three-month storage at room temperature were varied ranging from 0.374 ± 0.003 to 0.504 ± 0.035 depending on formulation compositions as shown in Table 4.…”

Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System

“…In alignment with such an achievement, various studies showed that SD formulations were able to enhance drug bioavailability compared to pure LZP [9,10]. Moreover, Ubgade et al prepared a nanosuspension formulation of LZP and in vitro dissolution showed that the prepared formulation was able to enhance initial and total drug dissolution behavior compared to the pure drug [11].…”

“…For example, Zhang et al prepared an SD formul using fluid-bed coating technology where 90% of drug was dissolved at the e iment [8]. In alignment with such an achievement, various studies showed th lations were able to enhance drug bioavailability compared to pure LZP [9,10 Ubgade et al prepared a nanosuspension formulation of LZP and in vitro showed that the prepared formulation was able to enhance initial and total d tion behavior compared to the pure drug [11]. Self-nanoemulsifying drug delivery systems (SNEDDSs) incorporate tants, and co-surfactants to form nano-scale emulsion droplets upon mild a hancing the surface area for dissolution and absorption compared to the dru Recent research incorporated naturally derived oils with biological activities a to potentially augment the therapeutic activity of administered therapeut [13].…”

Exploring the medicinal potential of in vitro cultures for enhanced production of metabolite empowered by green silver nanoparticles in Alhagi maurorum Medik

“…To ensure nanosuspension stability, a minimum zeta potential of ± 30 mV is typically required(Ubgade et al 2021). The negative zeta potential in silver nanoparticles, likely due to bio-organic capping from plant extracts, enables electrostatic repulsion, preventing agglomeration and ensuring stability(Liaqat et al 2022).…”