“…; M = Ti, Zr, Hf, and V; and X = F, Cl, Br, and I), are highly effective against Ehrlich ascites tumor cells, sarcoma 180, B16 melanoma, lymphoid leukemia L1210, lymphocytic leukemia P388, and colon 38 carcinoma. − The effectiveness of metallocenes as antitumor agents varies with the position of the metal atom in the periodic table . The carcinostatic activity of metallocenes is mechanistically similar to that other agents such as cisplatin, (NH 3 ) 2 PtCl 2 , targeting the nucleic acid metabolism and mitotic function. − Titanocene dihalides have been clinically tested in the past, and they proved to be drastic therapeutic drugs against arthritis. , Recently, much work has been done in testing these compounds, and physicochemical evidence for the antiarthritic activity of several metallocene complexes has been reported. − …”