Effect of Vagotomy on Pancreatic Secretion Stimulated by Endogenous and Exogenous Secretin

Moreland, Harris J.; Johnson, Leonard R.

doi:10.1016/s0016-5085(71)80123-3

Cited by 61 publications

(11 citation statements)

References 18 publications

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“…Thus, Moreland and Johnson (1970) observed a reduction in the pancreatic exocrine response to duodenal acid after vagotomy. There was no associated diminution in pancreatic sensitivity to exogenous secretin and these authors concluded that endogenous secretin release was impaired by vagal section.…”

Section: Discussionmentioning

confidence: 91%

Effect of vagotomy on secretin release in man.

Ward¹,

Bloom²

1975

Gut

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SUMMARY The release of secretin by intraduodenal acid has been measured by means of a highly sensitive radioimmunoassay in 12 normal subjects, 23 duodenal ulcer patients, and 14 vagotomized patients (6 TV + P; 4 SV + P; 4 HSV). A highly significant response occurred in all three groups. There was no significant difference between the groups either in the magnitude or timing of this response, though the absolute values for pre-stimulation and peak secretin were significantly smaller in preoperative duodenal ulcer patients than in either the normal subjects or the vagotomized patients. The secretin response was similar after truncal, selective, and highly selective vagotomy. These results suggest that secretin release is not dependent on intact vagal innervation of the small intestine in man.Vagal influences are known to be important in the release of gastrin (Grossman, 1967), but whether the vagus is involved in secretin release has not been established. The secretin response to duodenal acid has recently been measured in man using a radioimmunoassay (Ward and Bloom, 1974) and in the present study this work has been extended to include an assessment of the post vagotomy response. Methods SUBJECTSTwelve normal subjects (10 males; two females), 23 duodenal ulcer patients (21 males; two females), and 14 vagotomized patients (12 males; two females) were investigated. The mean ages in the three groups were 38 years (21-63 years), 42 years (27-67 years), and 45 years (30-66 years). The mean weights were 71 kg (55-83 kg), 68 kg (52-82 kg), and 68 kg (48-79 kg) respectively. In the vagotomized group, tests were undertaken six months or more after truncal vagotomy and pyloroplasty (six), selective vagotomy and pyloroplasty (four), and highly selective vagotomy (four). All the patients were insulin negative at the time of testing according to Hollander's original criteria (Hollander, 1948), as well as the criteria of subsequent authors (Waddell, 1957;Bachrach, 1962;Ross and Kay, 1964;Bank et al., 1967).Intraduodenal acid may inhibit gastric secretion in addition to provoking secretin release (Johnston and Duthie, 1964) and the present results were Received for publication 10 October 1975. obtained during tests in which both phenomena were studied. Details regarding the changes in acid output are described more fully elsewhere (Ward, 1974).Gastric secretion was stimulated by a continuous intravenous infusion of pentagastrin (6 ,tg/kg/hour in normal subjects and preoperative ulcer patients, 9 ,ug/kg/hour in vagotomized patients) and 10 minute gastric collections were made throughout each test. Once a secretory plateau had been reached, which was usually by an hour, 40 ml 0.1 N hydrochloric acid, at 37°C, were infused into the distal duodenum over a five minute period. Gastric collection was then continued for a further hour. Secretin levels were monitored at intervals throughout each test. Blood was withdrawn from an antecubital vein into heparin-trasylol, then rapidly centrifuged and deep frozen. Samples were taken at 10...

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Section: Discussionmentioning

confidence: 91%

Effect of vagotomy on secretin release in man.

Ward¹,

Bloom²

1975

Gut

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“…In an attempt to differentiate between vagal and hormonal control, both pharmacological and nerve section have been used. The effects of truncal vagotomy have been reported by many authors (Thomas, 1950 for early references; Tankel & Hollander, 1958;Magee, Fragola & White, 1965;Henriksen, 1969;Moreland & Johnson, 1971;Konturek, Becker & Thompson, 1974;Debas, Konturek & Grossman, 1975;Grundy et al 1983). In addition, pancreatic secretion has been studied after complete extrinsic denervation brought about by autotransplantation (Wang & Grossman, 1951;Singer, Solomon & Grossman, 1980;Kohler, Nustede, Barthel & Schafmayer, 1987).…”

Section: Introductionmentioning

confidence: 89%

Exocrine pancreatic function during cold blockade of the vagus in chronic experiments on calves

Zabielski¹,

Podgurniak²,

Pierzynowski³

et al. 1990

Experimental Physiology

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SUMMARYFour calves were prepared surgically to investigate the exocrine pancreatic function in chronic experiments. Cooling devices were implanted on both vagi for temporary, reversible, thermal blockade of the conductivity in the nerves. Cooling of the vagi caused significant decreases of volume, total protein content and trypsin activity in pancreatic juice. All of these variables recovered to the control level immediately after the cooling. Results presented indicate an important role of vagally driven information on the exocrine pancreatic secretion in calves.

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“…A neural component of secretin release has been previously postulated (Moreland and Johnson, 1971;O'Connor et al, 1976). Henriksen et al (1976) described a urecholine-stimulated change in pH threshold for its release in dogs.…”

Section: Discussionmentioning

confidence: 99%

Role of neural influences in the release of gastrin, glucagon, and secretin during hypoglycaemia in man.

McLoughlin¹,

Hayes²,

Buchanan³

et al. 1978

Gut

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BelfastSUMMARY Both vagal and sympathetic innervation been have described as influencing hormone release from the gastrointestinal tract and pancreas. The role of neural influences on the release of gastrin, glucagon, and secretin has been studied using the potent autonomic nerve stimulus of hypoglycaemia. Healthy subjects were each rendered hypoglycaemic by insulin 0-2 units/kg on three occasions: after atropine 20 pg/kg: after propranolol 160 mg orally, and without prior drug administration.Adequate beta-blockade was confirmed by observation of the pulse rate response to a standard exercise at the end of the experiment, and by measurement of plasma propranolol levels. Hypoglycaemia failed to produce a rise in plasma gastrin under either propranolol or control conditions but a significant rise was noted with prior atropinisation. The glucagon response to hypoglycaemia, when measured with either the C-or N-terminal reactive antibodies, was found not to be influenced to any significant extent by either beta-blockade or atropinisation. No alteration in plasma secretin levels was noted during hypoglycaemia. It therefore appears that neural influences are relatively unimportant in the release of gastrin, glucagon, and secretin in man.

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Effect of Vagotomy on Pancreatic Secretion Stimulated by Endogenous and Exogenous Secretin

Cited by 61 publications

References 18 publications

Effect of vagotomy on secretin release in man.

Effect of vagotomy on secretin release in man.

Exocrine pancreatic function during cold blockade of the vagus in chronic experiments on calves

Role of neural influences in the release of gastrin, glucagon, and secretin during hypoglycaemia in man.

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