Effect of UVB plus tar therapy on serum levels of interleukin-2 receptors in patients with psoriasis

Abstract

Baseline serum levels of interleukin-2 receptor (IL2R) were measured in 65 patients with active psoriasis. IL2R levels in psoriatic patients were significantly higher than in healthy controls (582.4 +/- 289.23 u/ml vs. 369.64 +/- 111.10 u/ml; P less than 0.05), but did not differ statistically from values found in an atopic dermatitis control group (619.88 +/- 254.27 u/ml). Sex, age and severity of the disease do not affect levels of IL2R. The same IL2R levels were measured in 26 psoriatic patients receiving UVB plus tar therapy. This therapy, continued until clinical remission, lowered IL2R levels to values comparable to controls. This decrease may be due to an immunosuppressive effect of therapy.

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

“…psoriasis, atopic dermatitis, etc.) (De Rie et al 1996, Kapp et al 1988, Betti et al 1991, Elias et al 1993, Kägi et al 1992, Kemmett et al 1990, of any immunological exponent that could serve as a marker for evaluation of disease severity, as well as for monitoring effectiveness of the applied therapy. Therefore, this study was undertaken to determine if there are biomarkers for the HS staging.…”