Effect of typical inducers of microsomal drug-metabolizing enzymes on phospholipid metabolism in rat liver

Ishidate, Kozo; Yoshida, Michiko; Nakazawa, Yasuo

doi:10.1016/0006-2952(78)90333-7

Cited by 20 publications

(2 citation statements)

References 39 publications

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“…Lipids appear to be removed from the plasma and accumulate in tissues in corn-oil–fed animals receiving PCB injection. A number of studies have reported an increase in liver and hepatic microsomal lipids (total lipids, phospholipids, neutral lipids, and cholesterol) after PCB administration (Asais-Braesco et al 1990; Garthoff et al 1977; Hinton et al 1978; Ishidate et al 1978; Robertson et al 1991). The amplified toxicity of linoleic acid and PCBs to endothelial cells could thus be mediated by cellular accumulation of this fatty acid and its subsequent transformation to toxic cytotoxic epoxide metabolites (Viswanathan et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to serum and vascular lipid changes, a number of studies have reported an increase in liver and hepatic microsomal lipids (total lipids, phospholipids, neutral lipids, and cholesterol) after PCB administration (Garthoff et al 1977; Ishidate et al 1978). Asais-Braesco et al (1990) reported that a single injection of PCB-77 resulted in a marked change in the fatty acid composition of rat hepatic microsomal fractions.…”

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confidence: 99%

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Dietary Fat Interacts with PCBs to Induce Changes in Lipid Metabolism in Mice Deficient in Low-Density Lipoprotein Receptor

Hennig¹,

Reiterer²,

Toborek³

et al. 2005

Environ Health Perspect

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There is evidence that dietary fat can modify the cytotoxicity of polychlorinated biphenyls (PCBs) and that coplanar PCBs can induce inflammatory processes critical in the pathology of vascular diseases. To test the hypothesis that the interaction of PCBs with dietary fat is dependent on the type of fat, low-density lipoprotein receptor–deficient (LDL-R−/−) mice were fed diets enriched with either olive oil or corn oil for 4 weeks. Half of the animals from each group were injected with PCB-77. Vascular cell adhesion molecule-1 (VCAM-1) expression in aortic arches was non-detectable in the olive-oil–fed mice but was highly expressed in the presence of PCB-77. PCB treatment increased liver neutral lipids and decreased serum fatty acid levels only in mice fed the corn-oil–enriched diet. PCB treatment increased mRNA expression of genes involved in inflammation, apoptosis, and oxidative stress in all mice. Upon PCB treatment, mice in both olive- and corn-oil–diet groups showed induction of genes involved in fatty acid degradation but with up-regulation of different key enzymes. Genes involved in fatty acid synthesis were reduced only upon PCB treatment in corn-oil–fed mice, whereas lipid transport/export genes were altered in olive-oil–fed mice. These data suggest that dietary fat can modify changes in lipid metabolism induced by PCBs in serum and tissues. These findings have implications for understanding the interactions of nutrients with environmental contaminants on the pathology of inflammatory diseases such as atherosclerosis.

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