The proliferation of hepatocytes and the lipid composition of the endoplasmic reticulum after induction of drug-metabolizing enzymes with trans-stilbene oxide

Suzuki, Yasuo; DePierre, Joseph W.; Ernster, Lars

doi:10.1016/0005-2736(80)90556-8

Cited by 24 publications

(2 citation statements)

References 41 publications

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“…Phenobarbitone, a well-known inducer of microsomal enzymes, increases total microsomal phospholipid [24]. traps-Stilbene oxide, another inducer of microsomal enzymes, decreases the cholesterol content of the endoplasmic reticulum, thereby increasing membrane fluidity [25]. The significant increase in liver microsomal phospholipids and decrease in cholesterol (Table 1) led to an increase in membrane fluidity (Table 1), which affects the membrane functions, and therefore, the activities of the drug-metabolizing enzymes associated with it, we consider the increase in content in all the different phospholipid fractions (Table 2) to be due to an increased incorporation of acetate into microsomal phospholipids (Fig.…”

Section: Resultsmentioning

confidence: 99%

Effect of Chloroquine on Rat Liver Microsomes.

Deepalakshmi

Parasakthy

Shanthi

et al. 1995

J. Clin. Biochem. Nutr.

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Section: Resultsmentioning

confidence: 99%

Effect of Chloroquine on Rat Liver Microsomes.

Deepalakshmi

Parasakthy

Shanthi

et al. 1995

J. Clin. Biochem. Nutr.

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“…Organic solvents were evaporated under nitrogen and samples sepa rated by thin-layer chromatography using a chloroform:methanol:acetic acid:water 25:15:4:2 v/v solvent system [17] and incorporating the respective standards were restored to the control level following drug administration to infected rats. How ever, with Suramin, the activity of these two enzymes was improved, but the levels never reached those of control rats.…”

Section: Lipid Analysismentioning

confidence: 99%

Response of the Rat’s Hepatic Drug-Metabolizing Enzyme System to Chemotherapy of Trypanosoma b. brucei Infections with Berenil and Suramin

Emerole¹,

Thabrew²

1984

Enzyme

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Berenil (4,4-diamidinodiazoaminobenzene-diacetamide acetate) or Suramin [sodium salt of 8-(3-benzamido-4-methylbenzamido)-naphthalene-l,3,5-trisulfonic acid] treatment of rats infected with Trypanosoma b. brucei enhanced hepatic microsomal aniline hydroxylase and p-aminopyrine N-demethylase activities. While Suramin inhibited significantly the activities of cytoplasmic glutamate dehydrogenase and lactate dehydrogenase, Berenil had no effect. The kinetic profiles of these enzymes consistently showed a K(m) value similar to that of controls. Both cytosolic and microsomal glutathione-S transferase and microsomal epoxide hydratase were unaffected by Suramin. However, a significant increase in cytosolic glutathione-S transferase was observed with Berenil. Microsomal phospholipids were not affected by any of the drugs.

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Cis- and trans-1,2-diphenylaziridines: induction of xenobiotic-metabolizing enzymes in rat liver and mutagenicity in Salmonella typhimurium

Glatt¹,

Robertson²,

Arand³

et al. 1986

Arch Toxicol

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trans-Stilbene imine (trans-1,2-diphenylaziridine) is the nitrogen analog of trans-stilbene oxide, a potent inducer of several microsomal and cytosolic xenobiotic-metabolizing enzymes. Although the acute toxicity of cis- and trans-stilbene imines prevents their application at the usual dose for trans-stilbene oxide (400 mg/kg/day), it is apparent that the imines nevertheless potently induce several xenobiotic-metabolizing enzymes in rat liver. The IP administration of trans-stilbene imine resulted in statistically significant increases in the activities of aminopyrine N-demethylase, microsomal epoxide hydrolase, glutathione transferase (toward 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene and delta 5-androstene-3,17-dione) and UDP-glucuronosyltransferase (toward testosterone). cis-Stilbene imine was less potent in inducing these activities. Although trans-stilbene imine (total dose = 400 mg/kg) was more potent than trans-stilbene oxide (total dose = 1200 mg/kg) in inducing the activities of glutathione transferase (toward 1-chloro-2,4-dinitrobenzene) and UDP-glucuronosyltransferase (toward testosterone), both compounds belong to the class of substances which are more potent inducers of conjugating (phase II) enzymes. Because of their structural similarity with K-region arene imines which are potent mutagens, cis-stilbene imine and trans-stilbene imine were investigated for mutagenicity (reversion of his- strains of Salmonella typhimurium). cis-Stilbene imine and trans-stilbene imine were direct mutagens in the strain TA100. This result, and the finding that acenaphthene 1,2-imine efficiently reverts various strains of Salmonella typhimurium, demonstrates that not only K-region arene imines, but also other aziridines substituted at the two carbons with aromatic moieties, are mutagenic.

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The proliferation of hepatocytes and the lipid composition of the endoplasmic reticulum after induction of drug-metabolizing enzymes with trans-stilbene oxide

Cited by 24 publications

References 41 publications

Effect of Chloroquine on Rat Liver Microsomes.

Effect of Chloroquine on Rat Liver Microsomes.

Response of the Rat’s Hepatic Drug-Metabolizing Enzyme System to Chemotherapy of Trypanosoma b. brucei Infections with Berenil and Suramin

Cis- and trans-1,2-diphenylaziridines: induction of xenobiotic-metabolizing enzymes in rat liver and mutagenicity in Salmonella typhimurium

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