Effect of Two Recently Developed Antiseptics on Dental Plaque and Caries in Rats

Shern, R.J.; Monell-Torrens, E.; Kingman, Albert

doi:10.1159/000260882

Cited by 17 publications

(15 citation statements)

References 10 publications

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“…This was confirmed on skin and wounds [83] and for plaque reduction in animal studies [89,90] . The residual effect of octenidine is remarkable [91,92] .…”

Section: Efficacymentioning

confidence: 60%

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Hübner

Siebert²,

Krämer³

2010

Skin Pharmacol Physiol

199

132

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Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well.

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“…This was confirmed on skin and wounds [83] and for plaque reduction in animal studies [89,90] . The residual effect of octenidine is remarkable [91,92] .…”

Section: Efficacymentioning

confidence: 60%

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Hübner

Siebert²,

Krämer³

2010

Skin Pharmacol Physiol

199

132

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“…The existing information suggests that a mouthrinse containing 0.1% OCT may be capable of exerting beneficial clinical effects upon plaque accumulation and gingivitis development (11–15). In oral rinse form, OCT was reported to inhibit dental plaque and caries in rats (16) and in humans (13). It has been demonstrated that OCT appears to be more effective than CHX as a means for prolonged bacterial anti‐adhesive activity (17).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antimicrobial activities of chlorhexidine gluconate, sodium hypochlorite and octenidine hydrochloride in vitro

et al. 2010

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The objective of this study was to compare the antimicrobial activity of sodium hypochlorite (NaOCl), chlorhexidine gluconate (CHX) and octenidine hydrochloride (OCT) in different concentrations against endodontic pathogens in vitro. Agar diffusion procedure was used to determine the antimicrobial activity of the tested materials. Enterococcus faecalis, Candida albicans and the mixture of these were used for this study. In the agar diffusion test, 5.25% NaOCl exhibited better antimicrobial effect than the other concentrations of NaOCl for all strains. All concentrations of OCT were effective against C. albicans and E. faecalis. Some 0.2% CHX was ineffective on all microorganisms. Antibacterial effectiveness of all experimental solutions decreased on the mixture of all strains. Decreasing concentrations of NaOCl resulted in significantly reduced antimicrobial effect.

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“…Chlorhexidine is a well-known anti septic with an excellent antiplaque and bactericidal activ ity [Addy. 1986], Studies in vitro [McDermid et al, 1987] and in vivo [Shern et al, 1985] indicate sensitivity of 5. mutans to chlorhexidine. In particular, this antiseptic showed a selective effect in the rat, eliminating S. mutans from the plaque on smooth surfaces and in fissures [Schaeken et al, 1984], The chlorhexidine concentration in the toothpaste used in the present study was 0.004%.…”

Section: Discussionmentioning

confidence: 99%

An in vitro Mouth Model to Test Antiplaque Agents: Preliminary Studies Using a Toothpaste Containing Chlorhexidine

Zampatti¹,

Roques²,

Michel³

1994

Caries Res

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The development of an in vitro model simulating the oral cavity has allowed the antiplaque activity of a toothpaste containing 0.004% chlorhexidine to be tested. The model is based on the continuous irrigation of bovine tooth samples with artificial saliva. Scanning electron microscopy showed homogeneous colonization of monobacterial plaque by Streptococcus mutans on dental surfaces under these model conditions. The enamel was colonized with regular cell clusters showing a globular appearance. The globules coalesced with increasing plaque thickness. Treatment with toothpaste containing 0.004% chlorhexidine showed a more marked inhibition of bacterial colonization on enamel surfaces than placebo paste lacking this antimicrobial agent. These results indicate that the toothpaste formulation is compatible with chlorhexidine. It is concluded that the in vitro model developed in this study is suitable for the testing of the antiplaque activity of antimicrobial agents, particularly when in a semisolid form such as in a toothpaste.

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Effect of Two Recently Developed Antiseptics on Dental Plaque and Caries in Rats

Cited by 17 publications

References 10 publications

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Evaluation of the antimicrobial activities of chlorhexidine gluconate, sodium hypochlorite and octenidine hydrochloride in vitro

An in vitro Mouth Model to Test Antiplaque Agents: Preliminary Studies Using a Toothpaste Containing Chlorhexidine

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