Effect of two hydatid cyst antigens on the growth of melanoma cancer in C57/black mice

Badri, Milad; Sharafi, Seyedeh Maryam; Rafiei-Sefiddashti, Raheleh; Jafari, Rasool; Bahadoran, Mehran; Pestechian, Nader; Darani, Hossein Yousofi

doi:10.1007/s12639-015-0643-7

Cited by 25 publications

(22 citation statements)

References 29 publications

(32 reference statements)

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“…Median survival time for HCC patients was 6 month (1-17). However, that was 8 month (3-90) for patients with both conditions, which was closely associated with tumor size, location, TMN stage and hydatid size, location, classification [28,29] and our results were highly accorded with previous studies. Importantly, four patients underwent surgical intervention and median survival time for them was 17 month (3-68), which was significantly longer than reported average level by some researchers that the median survival time for advanced HCC patients was only 3-5 month [5].…”

Section: Discussionsupporting

confidence: 91%

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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Purpose: Coexistence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the possible effects of echinococcal infection on HCC patients. Methods: Three thousand three hundred hepatic CE patients and 815 HCC patients were retrospectively reviewed between January 2010 and December 2018 in Xinjiang, China, and these patients were 1:5 matched according to their sex, age and tumor TMN stage, and only 13 patients coexisted both CE and HCC. Preoperative ultrasonography (US), computed tomography (CT), liver magnetic resonance imaging (MRI) and dot immune-gold filtration assay (DIGFA) were used for preoperative identification and intraoperative specimens from liver resections were pathologically examined for further confirmation. Survival time was analyzed through Cox proportional hazard model analysis. Results: The co-existing incidence rate of two diseases was 0.39%. For these concurrent cases, HCC was all at the advanced stage and CE lesions were inactive. Median survival time for HCC patients was 6 month (1-17). However, it was 8 month (3-90) for the co-existing cases and was much longer than the median survival time of HCC patients (P< 0.05), which was closely associated with tumor size, location, TMN stage and hydatid size, location, classification. Four of the patients underwent surgical intervention and their median survival time was 17 month (3-68). Conclusions: Echinococcus granulosus may elicit a protective effect against the development and progression of HCC, while more basic and clinical researches are needed.

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Section: Discussionsupporting

confidence: 91%

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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“…In this regard it has also been shown that T. gondii is able to generate therapeutic antitumor immunity against ovarian cancer (8). Besides T. gondii, anticancer activities of other parasites including Trypanpsoma cruzi (9), malaria parasite (10) and hydatid cyst [larval stage of Echinococcus granulosus (E. granulosus)] (11)(12)(13) have also been reported. The mechanisms underlying the anticancer effects of parasites are not well defined.…”

Section: Introductionmentioning

confidence: 99%

Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes

et al. 2019

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Toxoplasma gondii (T. gondii) is prevalent intracellular parasite and a cause of worldwide infection in the human population. An inhibitory effect of this parasite on cancer growth has been demonstrated in cell culture and animal models. To determine whether the anticancer activities of T. gondii are associated with host immune response, in the current study the reactivity of anti-T. gondii antiserum with the surface of cancer cell lines was investigated. Anti-T. gondii antibodies were raised in rabbit and the reaction of this antiserum in comparison with other anti-parasite antisera (anti-T. vaginalis, anti-hydatid cyst fluid, anti-protoscolices antigens) with mouse melanoma or breast cancer cells lines was investigated using flow cytometry. Anti-T. gondii antiserum reacted markedly with the surface of mouse melanoma and breast cancer cells, and less so with the normal mouse spleen lymphocytes. Meanwhile, the other anti-parasite antisera did not react strongly with the surface of cancer cells compared with normal mouse spleen lymphocytes. In summary, it has been demonstrated herein that anti-T. gondii antiserum may selectively react with the surface of mouse cancer cells but not with normal mouse spleen lymphocytes. Therefore, further study on anti-Toxoplasma antibodies may be useful for directing the application of selective drug delivery in cancer treatment.

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“…Melanoma cells were purchased from Pastor Institute and cultured in RPMI medium enriched with fetal bovine serum. The cells were then harvested for injection to mice as we did before [5].…”

Section: Methodsmentioning

confidence: 99%

“…In a retrospective study, it has been shown that in patients with hydatid cyst, incidence of different cancers was much lower than what exist in normal population [2]. Also the effect of different hydatid cyst antigens on inhi-H bition of the melanoma cancer growth has been reported in animal model [3][4][5] and in cell culture medium [6][7][8].…”

Section: Introductionmentioning

confidence: 99%