Effect of turnip leaf and root extracts on renal function in diabetic rats

Hassanzadeh-Taheri, Mohammadmehdi; Hosseini, Mehran; Hassanpour-Fard, Mohammad; Ghiravani, Zahra; Vazifeshenas-Darmiyan, Khadijeh; Yousefi, Somayeh; Ezi, Samira

doi:10.1007/s13596-016-0249-3

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…4, England), concentrated under vacuum evaporator, and lyophilized using a freeze-dryer (Dena Vacuum Industry, model FD-5005-BT, Iran). 13 The extraction yield was about 9.5 %.…”

Section: Plant Materialsmentioning

confidence: 95%

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

et al. 2019

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Background: The oleo-gum-resin of Commiphora myrrha (myrrh) has a long history of therapeutic use in traditional medicine. The aim of this study was to seek for the scientific evidence to determine whether the ethanolic extract of myrrh (EEM) has any beneficial effects on Streptozotocin (STZ) induced testicular impairments, and explore the possible mechanisms underlying such actions. Methods: Forty-eight severe and complicated diabetic rats (fasting blood glucose above 350 mg/dL), randomly were divided into six equal groups (n=8). Besides, eight healthy rats allocated as a normal control group and only treated with vehicle solution. The diabetic animals orally received the extract (100, 200, 300, and 500 mg/kg), metformin (500 mg/kg) or vehicle solution for 28 days. As a final point, plasma glucose and insulin, circulatory sex hormones, sperm parameters including sperm concentration, motility and viability and also testicular malondialdehyde (MDA) levels were assessed. Furthermore, quantitative histological evaluation of seminiferous tubules area and determination of germinal cells apoptosis were performed. Results: None of the studied doses of EEM showed anti-diabetic effects. However, the extract mainly at the maximum dose (500 mg/kg) exhibited beneficial effects on reproductive impairments. The EEM treated rats mainly at 500 mg/kg had significantly higher sperm concentration, sperm motility, sperm viability, sex hormones and lower testicular MDA and germ cell apoptosis index than untreated diabetic rats. Conclusion: These results indicated that EEM may have beneficial effects against reproductive dysfunction induced by diabetes. The mechanisms behind the effects might be associated with the EEM sex hormone booster potential, antioxidant and anti-apoptotic properties.

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“…4, England), concentrated under vacuum evaporator, and lyophilized using a freeze-dryer (Dena Vacuum Industry, model FD-5005-BT, Iran). 13 The extraction yield was about 9.5 %.…”

Section: Plant Materialsmentioning

confidence: 95%

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

et al. 2019

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“…34 Kidneys play pivotal role in excretion of metabolites and drugs, and regulating blood flow and many metabolic activities, hence they are highly susceptible to damage by drugs or herbs. 23,35 One of the important functions of kidneys is electrolytes balance. Sodium is the main extracellular cation; in contrast, potassium has considered the main intracellular cation.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological features including degeneration, congestion, infiltration and haemorrhage were assessed and scored for each microscopic field of kidney or liver sections according to a scoring checklist (0 = none, 1= mild, 2= moderate, 3= severe). 3,22,23…”

Section: Pharmaceutical Sciences March 2018 24 23-30 | 25mentioning

confidence: 99%

Acute and Sub-Acute Oral Toxicity Evaluation of Astragalus hamosus Seedpod Ethanolic Extract in Wistar Rats

Hassanzadeh-Taheri¹,

Hosseini²,

Salimi³

et al. 2018

Pharm Sci

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Background: Oral consumption of Astragalus hamosus L. (AH) seedpod has been widely prescribed in traditional medicine system. However, its toxicity evaluation has never been investigated. Hence, the current study was performed to evaluate the toxicological profile of AH seedpod in acute and subacute assessments based on the OECD-guidelines 425 and 407 in male and female Wistar rats. Methods: In the acute study, ethanolic extract of AH at a single dose of 2000 mg/kg was orally administrated to six female rats. In the subacute assay, AH at the three different oral doses (75, 150 and 300 mg/kg) were administrated to both male and female rats for 28 consecutive days. Results: No death or behavioural changes were observed in the treated animals. In subacute test, in both sexes, no changes in organ weights observed. Biochemically, compared to the control, AH at the dose of 300 mg/kg slightly increased (p<0.05) uric acid and creatinine and declined total cholesterol levels in both male and female rats. However, there is no statistically difference in other parameters such as albumin, triglyceride, blood urea, aspartate aminotransferase and alanine aminotransferase between AH treated groups and untreated controls. Hematologic parameters showed that AH at the maximum dose decreased red blood cells count only in male rats. Histopathological evaluation of liver and kidney exhibited no noticeable alterations in AH treated animals. Conclusion: It could be concluded that high excessive and long term consumption of AH may lead to renal dysfunction and deficiency in hematopoietic system.

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“…Performing pre-clinical studies in animal models of diabetes have been widely used to study different aspects of this disease and to pave the way for externalization of particular agents or therapeutic strategies to clinic. [7][8][9][10] Several experimental studies demonstrated that Streptozotocin (STZ) induced diabetes in rodents -particularly in rats-is a suitable model for studying this disease. However, there is evidence showing abnormalities of germ cells in the STZ-induced diabetic rats do not directly correlate with blood glucose levels.…”

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confidence: 99%

“…12 For this reason, most investigations using STZ-diabetic rats have followed for 4-6 weeks, 5 sometimes 8 weeks 13 or diabetic animals have been left untreated for 3-4 weeks before starting the experiment to develop chronic complications of diabetes like testicular impairment. 10,[14][15][16] The second important point which worth to be considered in the studies using animal models of diabetes is the number of diabetic animals. It is well documented that acute mortality rate within a week after STZ-injection was inversely correlated to animal age as well as weight.…”

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confidence: 99%

Comments on "The improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin"

Hassanzadeh-Taheri

Hosseini

2020

Pharm Sci

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Effect of turnip leaf and root extracts on renal function in diabetic rats

Cited by 12 publications

References 24 publications

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

Acute and Sub-Acute Oral Toxicity Evaluation of Astragalus hamosus Seedpod Ethanolic Extract in Wistar Rats

Comments on "The improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin"

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