Comments on "The improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin"

Hassanzadeh-Taheri, Mohammadmehdi; Hosseini, Mehran

doi:10.34172/ps.2019.60

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…The production of testosterone and sperms is the primary function of the testis [ 36 ]. Consequently, testosterone measurement is considered as a marker indicating optimal testicular function.…”

Section: Discussionmentioning

confidence: 99%

“…In the cross-section, the lumen of the seminiferous tubule is lined by Sertoli cells. It contains spermatozoa in various stages of development, from spermatogonia near the base of tubules to progressively mature forms (spermatocytes, spermatids, and spermatozoa) arranged towards the center of the lumen [ 36 ]. The most common pathological feature observed concerning the testicular toxicity is the germinal epithelium’s loosening [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common pathological feature observed concerning the testicular toxicity is the germinal epithelium’s loosening [ 38 , 39 ]. Therefore, quantitative assessment of germinal epithelium area or its diameter has been performed in different studies [ 1 , 30 , 31 , 36 ]. It is well-demonstrated that CIS affects testicular germinal epithelium by both cytotoxic effect and induction of apoptosis [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

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The protective effect of crocin on cisplatin-induced testicular impairment in rats

et al. 2021

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Background Side effects of cisplatin (CIS) such as testicular toxicity restrict its clinical use. Instead, evidence indicates that crocin (CR) has synergistic anti-cancer potential with CIS and exhibited beneficial effects on CIS-induced hepatorenal damage. The aim of this study was to investigate the protective potential of CR against CIS-induced testicular toxicity in rats. Methods Fifty adult male Wistar rats randomly assigned to five equal groups including control, CIS, and CIS plus CR at doses of 6.25 mg/kg (CIS + CR6.25), 25 mg/kg (CIS + CR25), and 100 mg/kg (CIS + CR100). CIS and CIS + CR groups received a single intraperitoneally (i.p.) injection of CIS (7 mg/kg). CR (6.25–100 mg/kg i.p.) injections were started three days before the CIS injection and continued once a day for up to 13 days. On the 14th day, all animals were sacrificed and their blood samples and testes were removed for biochemical and histological analyses. Results Compared to the control group, CIS significantly decreased relative testis weight (0.28 vs. 0.39, p < 0.001), testosterone level (0.3 vs. 2.31 ng/mL, p < 0.001), germinal layer area (25,886 vs. 35,320 µm2, p < 0.001), superoxide dismutase (SOD) (0.9 vs.1.73 U/mg, p < 0.001) and increased testicular lipid peroxidation (3.05 vs. 15.35 nmol/mg, p < 0.001). CR at 25 mg/kg ameliorated testicular lipid peroxidation and enhanced SOD activity compared to CIS group (p < 0.05). Besides, CR treatment at the maximum dose (100 mg/kg) resulted in reversing CIS effects on testis weight, testosterone level, SOD, lipid peroxidation, and germinal layer area. Conclusions These findings demonstrated that CR co-treatment could prevent CIS-induced testicular toxicity in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%