Investigating the effect of ethanolic extract of Commiphora myrrha (Nees) Engl. gum-resin against hepatorenal injury in diabetic rats

Hassanzadeh-Taheri, Mohammadmehdi; Salimi, Mojtaba; Vazifeshenas-Darmiyan, Khadijeh; Mohammadifard, Mahtab; Hosseini, Mehran

doi:10.1007/s40200-021-00904-1

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…It is a potent antibacterial medication used to treat brucellosis, glandular fever, sinusitis, gingivitis, mouth ulcers, and parasite infections [24,25]. Furthermore, the volatile oils from myrrh and their crude extracts showed a variety of biological actions, including cytotoxic, anesthetic, anti-inflammatory, antiviral, and antibacterial properties [26][27][28][29]. Previous phytochemical investigations have indicated that flavonoids, steroids, and lignans are frequently found in plant stems.…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatography–Mass Spectrometry Chemical Profiling of Commiphora myrrha Resin Extracts and Evaluation of Larvicidal, Antioxidant, and Cytotoxic Activities

Alanazi,

Alamri,

Mashlawi

et al. 2024

Molecules

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Plant extracts and essential oils can be alternative environmentally friendly agents to combat pathogenic microbes and malaria vectors. Myrrh is an aromatic oligum resin that is extracted from the stem of Commiphora spp. It is used in medicine as an insecticide, cytotoxic, and aromatic. The current study assessed the effect of Commiphora myrrha resin extracts on the biological potency of the third larval stage of Aedes aegypti, as well as its antioxidant and cytotoxic properties against two types of tumor cells (HepG-2 and Hela cell lines). It also used GC–MS to determine the chemical composition of the C. myrrha resin extracts. Fifty components from the extracted plant were tentatively identified using the GC–MS method, with curzerene (33.57%) typically listed as the primary ingredient, but other compounds also make up a significant portion of the mixture, including 1-Methoxy-3,4,5,7-tetramethylnaphthalene (15.50%), β-Elemene (5.80%), 2-Methoxyfuranodiene (5.42%), 2-Isopropyl-4,7-Dimethyl-1-Naphthol (4.71%), and germacrene B (4.35%). The resin extracts obtained from C. myrrha exhibited significant efficacy in DPPH antioxidant activity, as evidenced by an IC50 value of 26.86 mg/L and a radical scavenging activity percentage of 75.06%. The 50% methanol extract derived from C. myrrha resins exhibited heightened potential for anticancer activity. It demonstrated substantial cytotoxicity against HepG-2 and Hela cells, with IC50 values of 39.73 and 29.41 µg mL−1, respectively. Notably, the extract showed non-cytotoxic activity against WI-38 normal cells, with an IC50 value exceeding 100 µg mL−1. Moreover, the selectivity index for HepG-2 cancer cells (2.52) was lower compared to Hela cancer cells (3.40). Additionally, MeOH resin extracts were more efficient against the different growth stages of the mosquito A. aegypti, with lower LC50, LC90, and LC95 values of 251.83, 923.76, and 1293.35 mg/L, respectively. In comparison to untreated groups (1454 eggs/10 females), the average daily number of eggs deposited (424 eggs/L) decreases at higher doses (1000 mg/L). Finally, we advise continued study into the possible use of C. myrrha resins against additional pests that have medical and veterinary value, and novel chemicals from this extract should be isolated and purified for use in medicines.

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Section: Introductionmentioning

confidence: 99%

Gas Chromatography–Mass Spectrometry Chemical Profiling of Commiphora myrrha Resin Extracts and Evaluation of Larvicidal, Antioxidant, and Cytotoxic Activities

Alanazi,

Alamri,

Mashlawi

et al. 2024

Molecules

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“…Also, certain conditions to be followed post-STZ administration was not documented. Based on the literature survey conducted, various doses of STZ have been employed (40, [1][2][3] 45, 4-8, 50, 9 55, [10][11][12][13] 60, [14][15][16][17][18] 65 [19][20][21][22] mg/kg), (Table 1) to induce diabetes in Wistar rats. STZ was mostly dissolved in 10 mM sodium citrate buffer (pH 4.5) and a few instances in normal saline solution.…”

Section: Introductionmentioning

confidence: 99%

Subtle Intricacies Identified during Streptozotocin-Induced Diabetes in Wistar Rats

Brahmam¹,

Begum²,

Yarlagadda³

et al. 2023

Ind. J. Pharm. Edu. Res.

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Aim: This study aimed to establish the dose of streptozotocin required to induce Type -1 diabetes in Wistar rats. Background: Streptozotocin is currently employed worldwide to induce insulin-dependent diabetes mellitus also known as Type 1 diabetes mellitus in experimental animals. Though many reports on the use of streptozotocin induction of diabetes are reported in the literature, they were not reproducible. Moreover, there was no mention of the mortality associated with the same as well as the conditions followed during the study. Materials and Methods: In the present study, the dose, route, and solvent used for streptozotocin were investigated. Various doses of streptozotocin 55, 50, 40, and 35mg/kg dissolved in either freshly prepared cold 10mM sodium citrate buffer (pH 4.5) or normal saline solution was administered intraperitoneally as well as intravenously. For intraperitoneal administration, the dose-volume was 10mL/kg whereas for intravenous administration the dose-volume was 2mL/Kg. Different routes were employed to ascertain the cause of mortality for which an autopsy was performed. Besides mortality rate was also determined. Results and Discussion: The findings of the study revealed that a 35-40mg/kg dose of streptozotocin showed less percentage mortality and successful induction of diabetes. Conclusion: Mortality (10-20%) was observed at a dose of 35-40mg/kg streptozotocin. Therefore, streptozotocin (35-40mg/kg) was confirmed to be safe and effective for the induction of diabetes in Wistar rats. This paper highlights subtle intricacies observed during induction of diabetes in Wistar rats using streptozotocin

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Hydrogel patch with pretreated stem cells accelerates wound closure in diabetic rats

Andleeb

Mehmood

Tariq

et al. 2022

Biomaterials Advances

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Investigating the effect of ethanolic extract of Commiphora myrrha (Nees) Engl. gum-resin against hepatorenal injury in diabetic rats

Cited by 3 publications

References 39 publications

Gas Chromatography–Mass Spectrometry Chemical Profiling of Commiphora myrrha Resin Extracts and Evaluation of Larvicidal, Antioxidant, and Cytotoxic Activities

Gas Chromatography–Mass Spectrometry Chemical Profiling of Commiphora myrrha Resin Extracts and Evaluation of Larvicidal, Antioxidant, and Cytotoxic Activities

Subtle Intricacies Identified during Streptozotocin-Induced Diabetes in Wistar Rats

Hydrogel patch with pretreated stem cells accelerates wound closure in diabetic rats

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