Effect of turmeric on alloxan induced diabetes mellitus in albino rats

Abstract

Background: Diabetes mellitus is a chronic metabolic disorder of glucose metabolism characterised by hyperglycaemia. Long standing diabetes mellitus leads to various complications affecting multiple organ systems. Management of diabetes mellitus includes lifestyle modification and pharmacotherapy. Pharmacotherapy of diabetes mellitus includes a wide variety of drugs that help in achieving adequate glycaemic control. Anti-diabetic medications are however associated with several adverse effects. Phytochemicals are being used extensively for the treatment of various diseases. Use of phytochemicals would minimize adverse effects due to various anti-diabetic drugs and improve patient compliance. In the present study, authors studied the effect of turmeric on alloxan induced diabetes mellitus in albino rats.Methods: Albino Wistar rats of either sex weighing 180 - 250grams were utilized for the present study. Diabetes mellitus was induced by intraperitoneal administration of alloxan. Ethanolic extract of turmeric was administered to diabetic rats daily orally for duration of 28 days. Blood glucose levels were monitored using glucometer before and after intervention with turmeric.Results: Statistically significant reduction in mean blood glucose levels (p value <0.05) was seen after intervention with turmeric in diabetic rats. There was a significant reduction in mean blood glucose levels.Conclusions: Ethanolic extract of turmeric showed antihyperglycemic effect in diabetic rats.

Curcuma longa modulates Islet β-cell function and insulin resistance in diabetic rat.

“…23 We found elevated serum insulin levels in high dose fed rats (Table-I) that is caused by stimulation of β -cell function, this is in keeping with previous studies. 24,25 In summary, we found improved βcell function (HOMA-β) with reduction in Insulin resistance (HOMA-IR) and significant correction of glycemic indices. It is concluded the Curcuma longa exhibits excellent stimulation of β -cells functioning and mitigation of insulin resistance that may be exploited for treating type 2 diabetic subjects but this needs large scale studies.…”

Antihyperglycemic effect of turmeric aqueous root extract and morphological changes in the pancreas of alloxan-induced hyperglycemic Wistar rats

“…This, according to them was because of its ability to reduce hepatic glucose production. In a related study, using an animal model, Padhye et al 15 reported a significant reduction in blood glucose levels in diabetic induced Wistar rats. Similarly, Tsiani et al 3 in a review study reported the antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties of turmeric extract.…”