Effect of tryptophan on fatty acid synthesis in rat liver

Differential effects of tryptophan on glucose synthesis in rats and guinea pigs

“…The administration of tryptophan to rats at pharmacological doses is associated with a variable hypoglycaemia (Gullino et al, 1955;Mirsky et al, 1956;McDaniel et al, 1973;Smith & Pogson, 1977), inhibition of hepatic gluconeogenesis (Ray et al, 1966;Oravec & Sourkes, 1967;McDaniel et al, 1972;Smith & Pogson, 1977), increased fatty acid synthesis (Sakurai et al, 1973(Sakurai et al, , 1974Miyazawa et al, 1975), increased ribosomal aggregation (Wunner et al, 1966;Baglia et al, 1968;Sidransky et al, 1968), and changes in the total activities of specific enzymes (Greengard et al, 1963;Rosen & Milholland, 1963;Cihak et al, 1973Cihak et al, , 1975Ballard & Hopgood, 1973).…”