The effect of quinolinic acid on the content and distribution of hepatic metabolites

Spydervold, O.S.; Zaheer-Baquer, Najma; McLean, Patricia; Greenbaum, A. L.

doi:10.1016/0003-9861(74)90071-x

Cited by 19 publications

(10 citation statements)

References 31 publications

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“…respectively with 5 mM-quinolinate. These changes are similar to those noted by Williamson et al (1971) and Spydervold et al (1974). As a comparison, the corresponding values with 0.5mM-tryptophan (a concentration which gives a pronounced inhibition of gluconeogenesis from lactate) were 3.4 and 5.7nmol/ mg dry wt.…”

Section: Methodssupporting

confidence: 90%

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Permeability of the liver cell membrane to quinolinate

Elliott¹,

Pogson²,

Smith³

1977

Biochemical Journal

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Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.

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Section: Methodssupporting

confidence: 90%

“…Re-examination of the data of Hagino et al (1968), however, suggests that quinolinate may actually penetrate the liver cell quite effectively. Later studies have, in addition, indicated that quinolinate may not in fact act in the manner proposed by Lardy and co-workers (Spydervold et al, 1974).…”

mentioning

confidence: 92%

Permeability of the liver cell membrane to quinolinate

Elliott¹,

Pogson²,

Smith³

1977

Biochemical Journal

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“…This may once more reflect changes in the cytosolic concentrations of 2-oxoglutarate and glutamate. Spydevold et al (1974) calculated that quinolinate, which accumulates during tryptophan metabolism in the rat (McDaniel et al, 1973;Smith et al, 1980), causes a fall of two-thirds in cytosolic glutamate and a fall in 2-oxoglutarate to about 16% of its control value; such changes, if they persist in isolated liver cells, would be consistent with the present observations.…”

Section: Effect Of Tryptophan Administrationsupporting

confidence: 90%

The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells

Salter¹,

Stanley²,

Fisher³

et al. 1984

Biochemical Journal

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Liver cells from fed Sprague-Dawley rats metabolized phenylalanine, tyrosine and tryptophan at rates consistent with the known kinetic properties of the first enzymes of each pathway. Starvation of rats for 48 h did not increase the maximal activities of phenylalanine hydroxylase, tryptophan 2,3-dioxygenase and tyrosine aminotransferase in liver cell extracts, when results were expressed in terms of cellular DNA. Catabolic flux through the first two enzymes was unchanged; that through the aminotransferase was elevated relatively to enzyme activity. This is interpreted in terms of changes in the concentrations of 2-oxoglutarate and glutamate. Cells from tryptophan-treated animals exhibited significant increases in the catabolism of tyrosine and tryptophan, but not of phenylalanine. The activities of tyrosine aminotransferase and tryptophan 2,3-dioxygenase were also increased, although the changes in flux and enzyme activity did not correspond exactly. These results are discussed with reference to the control of aromatic amino acid catabolism in liver; the role of substrate concentration is emphasized.

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“…*Significant difference when compared with the control at P < 0.05. acute heat. Interestingly, increased quinolinic acid might contribute to increased lactic acid; the administration of quinolinic acid has been shown to increase lactic acid levels in rat livers (Spydervold et al 1974), and a positive relationship has been confirmed between quinolinic acid and lactic acid levels in the present study. Moreover, plasma pyruvic acid, which can be converted into lactic acid and vice versa by lactate dehydrogenase, was decreased in the present study.…”

Section: Discussionsupporting

confidence: 75%

“…We quantified this metabolite to recheck our result because it induces oxidative stress (Fujigaki et al 2017) and is involved in several metabolic pathways (Spydervold et al 1974); these functions could be linked to responses to high ambient temperature in chickens. On the basis of the results of non-targeted analysis, we focused on quinolinic acid.…”

Section: Introductionmentioning

confidence: 99%

Effects of high ambient temperature on plasma metabolomic profiles in chicks

Tomonaga

Okuyama

Tachibana

et al. 2017

Animal Science Journal

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Exposure to high ambient temperature is detrimental to the poultry industry. To understand the influence from a metabolic perspective, we investigated the effects of exposure to high ambient temperature on plasma low-molecular-weight metabolite levels in chicks using gas chromatography/mass spectrometry-based non-targeted metabolomic analysis. Heat exposure for 4 days suppressed growth and food intake. Of the 92 metabolites identified, the levels of 29 decreased, whereas the levels of nine increased. We performed an enrichment analysis on the identified metabolites and found 35 candidates for metabolic processes affected by heat exposure. Among them, the sulfur amino acid metabolic pathway was clearly detected and the levels of the following related metabolites were decreased: cystathionine, cysteine, cystine, homocysteine and hypotaurine. Changes in the kynurenine pathway in tryptophan metabolism, which is linked to the immune system and oxidative stress, were also observed: kynurenine and quinolinic acid levels increased, whereas nicotinamide levels decreased. These results suggest the possible involvement of various metabolic processes in heat-exposed chicks. Some of these metabolites would be important to understand the mechanism of biological responses to high ambient temperature in chicks.

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The effect of quinolinic acid on the content and distribution of hepatic metabolites

Cited by 19 publications

References 31 publications

Permeability of the liver cell membrane to quinolinate

Permeability of the liver cell membrane to quinolinate

The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells

Effects of high ambient temperature on plasma metabolomic profiles in chicks

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