Effect of Tripeptides on Lymphoid and Stem Cells

Abstract

Tripeptides T-36 and, particularly, T-38 in concentrations of 0.1, 1, and 10 ng/ml inhibited proliferation of primary trypsinized embryonic mesenchymal stem cells, rat transplantable KF-1 fibroblasts, and human erythromyelosis K-562 cells. Inhibition of proliferation in embryonic and immortalized cells under the influence of tripeptides probably reflects antitumor activity of these substances. Tripeptides had no effect on lymphocyte survival and their adhesive, cytotoxic, and induced proliferative activities. T-36 did not modulate the proliferative properties of erythromyelosis K-562 cells. Tripeptides did not change engulfment activity and spontaneous and induced bactericidal activities of granulocytes. T-36 in a concentration of 0.1 ng/ml increased spontaneous proliferation of normal lymphocytes. These data suggest that tripeptides stimulate nontumor immune cells in adult people.

Effect of short peptides on neuronal differentiation of stem cells

“…EDP peptide enhances the spontaneous proliferative activity of normal lymphocytes, which may indicate the stimulating effect of peptides on non-neoplastic immune cells of adult donors. 17…”

“…EDP peptide enhances the spontaneous proliferative activity of normal lymphocytes, which may indicate the stimulating effect of peptides on non-neoplastic immune cells of adult donors. 17 The effect of pineal gland and cerebral cortex synthetic peptides on the differentiation of the pluripotent ectodermal tissue of the early gastrula of the spiny frog Xenopus laevis is demonstrated. The AEDG (Ala-Glu-Asp-Gly) peptide stimulated the differentiation of the polypotent tissue into the epidermis and neural tissue, and the AEDP peptide induced the development of the mesenchyme and epidermis.…”

The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity

“…The inhibition of proliferation under the action of crystagen, which is directed at immortalized cells, may indicate its antitumor activity. The EDP peptide enhances the spontaneous proliferative activity of normal lymphocytes; this shows that it has a stimulating effect on nontumor human immune cells (Khavinson et al, 2011b). The oral administration of crystagen in combination with other short peptides increases stress resistance and normalizes immunity in athletes.…”