Effect of Triiodothyronine on Cyclic Amp and Pulmonary Function Tests in Bronchial Asthma

Khalek, Karima A. Abd El; Kholy, Mohamed El; Rafik, Mona; Fathalla, Mahmoud M; Heikal, E.

doi:10.3109/02770909109110625

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Measuring the level of eCO in COPD cases along with spirometry forms a new approach for better understanding of pathophysiology of COPD cases. 14 correspondence and reprint requests: Dr Mohammad Shameem, Professor, Department of Tuberculosis and Respiratory Diseases, JLN Medical College, Aligarh Muslim University, Aligarh-202 002 (Uttar Pradesh), India; E-mail: drshameem123@ gmail.com increased in bronchial asthma and COPD. 15 The present study was carried out to know whether eCO levels had any association with the disease severity in various stages of COPD.…”

Section: Introductionmentioning

confidence: 99%

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

Shameem¹,

Ejazi²,

Shahnawaz³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Background. Chronic obstructive pulmonary disease (COPD) is a general name for the chronic airflow obstruction that develops most commonly due to long term tobacco smoking and other noxious gases. The aim of the present study is to check whether exhaled carbon monoxide (CO) levels had any co-relations with disease severity in various stages of COPD.Methods. The clinical severity of asthma and COPD was determined using the criteria defined in the Global Initiative for Asthma (GINA) and Global Initiative for chronic obstructive pulmonary disease (GOLD) guidelines. Spirometry was used to confirm the presence of airway obstruction. results. We observed that exhaled CO levels increased with increasing severity of airway obstruction. A statistically significant negative correlation was observed between forced expiratory volume in the first second and exhaled CO (p<0.05).conclusions. We found that measuring the level of exhaled CO in patients with COPD along with spirometry forms a new approach for better understanding of the pathophysiology of COPD cases. [indian j chest dis allied sci 2019;61: [83][84][85][86]

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Section: Introductionmentioning

confidence: 99%

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

Shameem¹,

Ejazi²,

Shahnawaz³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Endocrine regulation of airway contractility is overlooked

Bossé

2014

Journal of Endocrinology

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Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the smooth muscle surrounding the airways, as well as a propensity of the airways to narrow excessively in response to a spasmogen (i.e. contractile agonist), a feature called airway hyperresponsiveness. The level of airway smooth muscle (ASM) activation is putatively controlled by mediators released in its vicinity. In asthma, many mediators that affect ASM contractility originate from inflammatory cells that are mobilized into the airways, such as eosinophils. However, mounting evidence indicates that mediators released by remote organs can also influence the level of activation of ASM, as well as its level of responsiveness to spasmogens and relaxant agonists. These remote mediators are transported through circulating blood to act either directly on ASM or indirectly via the nervous system by tuning the level of cholinergic activation of ASM. Indeed, mediators generated from diverse organs, including the adrenals, pancreas, adipose tissue, gonads, heart, intestines, and stomach, affect the contractility of ASM. Together, these results suggest that, apart from a paracrine mode of regulation, ASM is subjected to an endocrine mode of regulation. The results also imply that defects in organs other than the lungs can contribute to asthma symptoms and severity. In this review, I suggest that the endocrine mode of regulation of ASM contractility is overlooked.

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Utility of measuring Exhaled Carbon Monoxide (ECO) level in addition to Pulmonary Function Test (Spirometry) in the monitoring of Chronic Obstructive Pulmonary Disease (COPD)

Yuvarajan¹

2014

Int J Med Sci Public Health

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Background: The measurement of ECO may represent a new method for the non-invasive monitoring of airway inflammation and oxidant stress in Chronic Obstructive Pulmonary Disease, asthma, bronchiectasis, cystic fibrosis patients. Quantification of lung oxidative stress in stable COPD patients by measuring ECO levels may also contribute to the understanding of the pathophysiology of COPD. Aims & Objective:To study the utility of measuring Exhaled Carbon Monoxide (ECO) level in addition to Pulmonary Function Test (Spirometry) in the monitoring of Chronic Obstructive Pulmonary Disease (COPD). Materials and Methods: COPD patients who were smokers and with a history of exposure to wood smoke (n =60) and healthy nonsmokers as control (n =40) were selected as subjects by fulfilling the exclusion criteria as per the GOLD guidelines. Clinical examinations and spirometry including reversibility test were made following the standard protocol/procedure. ECO was measured using a MICRO III Smokerlyser. Results: The difference in level of ECO between COPD cases and healthy non-smokers was highly significant (F = 23.897; df = 98; p < 0.0001). The difference in the level of ECO among different groups (mild, moderate, severe and very severe) was highly significant (F=15.995; df =2; p<0.0001). ECO level in female COPD cases who were exposed to wood smoke was elevated (4.11 ± 1.323) when compared to healthy female non-smokers (1.50 ± 0.519) and the difference was highly significant. (F =1.593; df = 30; p < 0.0001). Conclusion: ECO levels in COPD cases vary with different grades of air way obstruction. We concluded that measuring the level of ECO in COPD cases along with spirometry forms a new approach for better understanding of pathophysiology of COPD cases, with indirect assessment of airway inflammation, oxidative stress and severity of airway obstruction.

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Effect of Triiodothyronine on Cyclic Amp and Pulmonary Function Tests in Bronchial Asthma

Cited by 3 publications

References 10 publications

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

Endocrine regulation of airway contractility is overlooked

Utility of measuring Exhaled Carbon Monoxide (ECO) level in addition to Pulmonary Function Test (Spirometry) in the monitoring of Chronic Obstructive Pulmonary Disease (COPD)

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