Utility of measuring Exhaled Carbon Monoxide (ECO) level  in addition to Pulmonary Function Test (Spirometry) in the monitoring of Chronic Obstructive Pulmonary Disease (COPD)

Yuvarajan, S

doi:10.5455/ijmsph.2013.181220131

Cited by 3 publications

(5 citation statements)

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“…[ 50 ] There was negative correlation between eCO levels in COPD patients and lung function (FEV1 values) and it was statistically significant ( P < 0.01), similar to previous study. [ 6 ] However, our results differ from a study that showed no negative correlation between CO levels and lung function. [ 48 ]…”

Section: Discussioncontrasting

confidence: 99%

“…We have large sample size with adequate number of participants in each group as compared to the previous studies. [ 6 38 48 49 ] To the best of our knowledge, only one study from India by Sivagnaname had been published till now. [ 6 ] Hence, our study is second from India.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 3 4 5 ] There are limitations with the use of FEV1, since changes in it over time are small in relation to repeatability of the measurement. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

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Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

et al. 2018

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Introduction:Amplification of airway inflammation and its destruction due to oxidative stress is a major step in the pathogenesis of chronic obstruction pulmonary disease (COPD). Exhaled carbon monoxide (eCO) may be quantified to evaluate the airway inflammation and oxidative stress in such patients.Objectives:To assess the disease severity of COPD and treatment response by measuring eCO as a biomarker.Materials and Methods:COPD patients diagnosed according to the global initiative for chronic obstructive lung disease guidelines and healthy individuals as controls were selected. One hundred and fifty patients with COPD and 125 controls were included in the study. Participants were further subdivided on the basis of their smoking habits. Clinical examinations and spirometry were done to diagnose COPD by following the standard protocol. eCO was measured using a piCO + Smokerlyzer (Breath CO Monitor, Bedfont Scientific Ltd., Kent, UK). It was a single-center cross-sectional study.Results:Mean (± standard error of mean) CO levels in ex-smokers with COPD were higher (5.21 ± 1.546 ppm; P < 0.05) than in nonsmoking controls (1.52 ± 0.571 ppm) but were lower than in current smokers with COPD (12.55 ± 4.514 ppm; P < 0.05). eCO levels were higher in current smokers with COPD (12.55 ± 4.514 ppm; P < 0.05) compared to healthy smokers (9.71 ± 5.649). There was a negative correlation between eCO and forced expiratory volume in 1 s (FEV1) in COPD (r = −0.28; P < 0.05). The mean eCO level was decreased (6.291–4.332; P < 0.001) with improvement in lung function (FEV1 38.75%–50.65%: P < 0.05) after treatment with inhaled steroid.Conclusion:Our study concludes that quantification of eCO level in COPD varies with different grades of airway obstruction and to measure the treatment response. Measuring the level of eCO can be used to assess the indirect assessment of airway inflammation, oxidative stress, and severity of airway obstruction in COPD patients.

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Section: Discussionmentioning

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Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

et al. 2018

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“…This is explained by increased oxidative stress in the COPD group. In our study, exhaled CO was higher in the severe COPD group (mean 11.32 ± 3.15) compared to between the mild (9.54 ± 3.32) and the moderate (10.44 ± 2.43) COPD but without statistically significant difference with p-value 0.122, and there was a negative correlation between exhaled CO and FEV1 with p-value 0.04 which is similar to results of Sivagnaname (2014) study [16], but our results were different from Montuschi et al (2001) study [15] that found no negative correlation between exhaled CO levels and pulmonary function.…”

Section: Discussionsupporting

confidence: 87%

Role of exhaled carbon monoxide in assessment of chronic obstructive airway disease severity

Gawad,

Morsi,

Fayiad

2024

Egypt J Bronchol

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Background Chronic obstructive pulmonary disease (COPD) is a critical public health issue. Spirometric measurements are used to diagnose chronic obstructive lung disease, as per the guidelines of the GOLD initiative. Post-bronchodilator forced expiratory volume in 1 s (FEV1) is a predictor of mortality from COPD and helps to classify the disease’s severity. Smoking contributes to the high levels of exhaled CO. Evidence suggests that the exhaled CO level in COPD patients varies with degree of blockage and can be used to assess treatment response. Estimating the exhaled CO level can help assess airway inflammation and severity of airflow obstruction in individuals with COPD. Aim Evaluate role of exhaled CO in assessment of severity of COPD. Materials and methods This cross-sectional study included 132 patients who visited the outpatient clinics or were admitted to the Chest Department, Kasr Alainy Hospital, Faculty of Medicine, Cairo University. The study participants were divided into three groups: group 1 nonsmoker healthy control, group 2 smoker non-COPD, and group 3 smoker COPD which further divided according to GOLD 2023 into mild, moderate, and severe COPD. The smoking status, exhaled CO, and spirometry test including FEV1/FVC and FEV1 were measured for each patient. Results Exhaled CO was significantly increased in the smoker group (mean 9.69, SD 3.11) compared to the nonsmoker group (mean 2.19, SD 0.98) with p-value < 0.001. Exhaled CO was also statistically significantly higher in the smoker COPD group (mean 10.45, SD 3.03) compared to the smoker non-COPD group (mean 7.05, SD 1.56) with p-value < 0.001. Although exhaled CO was increased in the severe COPD group compared to the mild and moderate group, there is no statistically significant difference between them. Conclusion Exhaled CO is a fast, sensitive, noninvasive, and well-established method test that can be used to identify smokers from nonsmokers with 98.9% sensitivity at 4.5 cutoff value. Also, exhaled CO levels in COPD patients vary with different degrees of airway obstruction.

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“…So measuring the level of eCO in patients with COPD along with spirometry forms a new approach for better understanding of the pathophysiology of COPD. 24…”

Section: Figures In Parentheses Indicate Number Of Patients Along Wit...mentioning

confidence: 99%

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

Shameem¹,

Ejazi²,

Shahnawaz³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Background. Chronic obstructive pulmonary disease (COPD) is a general name for the chronic airflow obstruction that develops most commonly due to long term tobacco smoking and other noxious gases. The aim of the present study is to check whether exhaled carbon monoxide (CO) levels had any co-relations with disease severity in various stages of COPD.Methods. The clinical severity of asthma and COPD was determined using the criteria defined in the Global Initiative for Asthma (GINA) and Global Initiative for chronic obstructive pulmonary disease (GOLD) guidelines. Spirometry was used to confirm the presence of airway obstruction. results. We observed that exhaled CO levels increased with increasing severity of airway obstruction. A statistically significant negative correlation was observed between forced expiratory volume in the first second and exhaled CO (p<0.05).conclusions. We found that measuring the level of exhaled CO in patients with COPD along with spirometry forms a new approach for better understanding of the pathophysiology of COPD cases. [indian j chest dis allied sci 2019;61: [83][84][85][86]

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Utility of measuring Exhaled Carbon Monoxide (ECO) level in addition to Pulmonary Function Test (Spirometry) in the monitoring of Chronic Obstructive Pulmonary Disease (COPD)

Cited by 3 publications

References 37 publications

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

Role of exhaled carbon monoxide in assessment of chronic obstructive airway disease severity

To Study Association Between Exhaled Carbon Monoxide Levels with Disease Severity in Various Stages of Obstructive Airway Disease

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