Effect of triclosan (TRN) on energy-linked functions of rat liver mitochondria

Newton, Ana Paula Negrelo; Cadena, Sílvia Maria Suter Correia; Rocha, Maria Eliane Merlin; Carnieri, Eva Gunilla Skare; Oliveira, Maria Benigna Martinelli de

doi:10.1016/j.toxlet.2005.06.004

Cited by 72 publications

(39 citation statements)

References 38 publications

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“…Further, organic solvents were not employed to dissolve TCS, which might further suppress the level of absorption into cells. Similar results were found by Newton et al (2005) using direct measurement of TCS absorbed into isolated rat liver mitochondria, where 2.5 nmol of TCS/mg of protein was shown to produce mitochondrial uncoupling. Escarrone et al (2016) detected TCS at 0.49 nmol TCS/mg of protein in fish brain again demonstrating tissue antimicrobial concentrations at levels known to produce adverse effects.…”

Section: Triclosan Exposure Levels In Humanssupporting

confidence: 84%

“…This topic was recently reviewed by Ruszkiewicz et al (2017). Briefly, TCS was found to affect mitochondrial function (Weatherly et al 2016; Shim et al 2016; Newton et al 2005; Ajao et al 2015), disrupt proper calcium signaling (Cherednichenko et al 2012), alter zinc homeostasis (Tamura et al 2012), and affect immunological parameters (Anderson et al 2013; Yueh et al 2014; Udoji et al 2010; Weatherly et al 2013). …”

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

“…As previously indicated, several studies showed that TCS exhibited endocrine disrupting effects, which may account for a portion of the adverse reproductive outcomes observed in the epidemiological studies. Mitochondrial disruption by antimicrobial (Weatherly et al 2016; Ajao et al 2015; Newton et al 2005) may also contribute to adverse reproductive effects as proper mitochondrial function is required for embryonic development (Chen et al 2003). …”

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

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Triclosan exposure, transformation, and human health effects

Weatherly

Gosse

2017

Journal of Toxicology and Environmental Health, Part B

389

207

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Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the U.S.A. population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the U.S.A. Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. Triclosan is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems was also summarized.

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Section: Triclosan Exposure Levels In Humanssupporting

confidence: 84%

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

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Triclosan exposure, transformation, and human health effects

Weatherly

Gosse

2017

Journal of Toxicology and Environmental Health, Part B

389

207

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“…The pH range associated with each aquatic toxicity test is reported, if available (Table 5), because triclosan dissociation varies within the normal pH range of surface water (Orvos et al 2002). Toxicity is thought to be associated primarily with the neutral form.…”

Section: Effects Assessmentmentioning

confidence: 99%

Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissues

Lyndall

Fuchsman

Bock

et al. 2010

Integr Envir Assess & Manag

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Triclosan, an antimicrobial compound used in personal care products, occurs in the aquatic environment due to residual concentrations in municipal wastewater treatment effluent. We evaluate triclosan-related risks to the aquatic environment, for aquatic and sediment-dwelling organisms and for aquatic-feeding wildlife, based on measured and modeled exposure concentrations. Triclosan concentrations in surface water, sediment, and biota tissue are predicted using a fugacity model parameterized to run probabilistically, to supplement the limited available measurements of triclosan in sediment and tissue. Aquatic toxicity is evaluated based on a species sensitivity distribution, which is extrapolated to sediment and tissues assuming equilibrium partitioning. A probabilistic wildlife exposure model is also used, and estimated doses are compared with wildlife toxicity benchmarks identified from a review of published and proprietary studies. The 95th percentiles of measured and modeled triclosan concentrations in surface water, sediment, and biota tissues are consistently below the 5th percentile of the respective species sensitivity distributions, indicating that, under most scenarios, adverse affects due to triclosan are unlikely.

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“…The high sensitivity of algae to triclosan is likely related to its antibacterial characteristics that may affect various mechanisms, such as lipid synthesis (LU;ARCHER;FRANZ et al, 2008), stabilization of cell membrane or uncoupling phosphorylation (NEWTON et al, 2005) since these mechanisms are very similar to bacteria and algae (COOGAN et al, 2007;BRAUSCH;RAND, 2011).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and risk assessment of parabens and triclosan in surface waters of southern Brazil: a problem of emerging compounds in an emerging country

Santos

Brehm

Filippe

et al. 2016

RBRH

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Parabens and triclosan compounds are widely used in pharmaceutical products, personal care, food and various products of daily use. After use, the final destinations of these contaminants are domestic effluents and the environment if not collected or treated. The objective of this study was to evaluate the presence of parabens and triclosan in environments in a subtropical region, more specifically in the metropolitan region of Curitiba (southern Brazil) and possible effects of these compounds in aquatic environments through risk assessment through the use of risk quotient (RQ). Samples were collected in 20 points for 4 campaigns. For the extraction of the compounds we used the extraction technique of solid phase extraction (SPE). The determination of the compounds was using gas chromatography coupled to mass spectrometry (GC-MS). It was observed high concentrations of parabens, especially MeP (up to 2875 ng L -1). Despite high concentrations of parabens, their presence has a low risk to aquatic organisms. Triclosan has been observed at higher concentrations (415 ng L -1 ), suggesting once again that these environments are impacted by human action. The RQ assessed that triclosan has a high risk for certain groups of organisms.Keywords: Emerging pollutants; Risk assessment; Triclosan; Parabens; Domestic sewage. RESUMOParabenos e triclosan são usados amplamente na composição de produtos farmacêuticos, cuidado pessoal, alimentos e diversos produtos de uso cotidiano. Após seu uso, o destino final destes contaminantes são os efluentes domésticos e o meio ambiente, caso não seja coletado ou tratado. A presença destes poluentes emergentes podem apresentar efeitos adversos ao meio ambiente. O objetivo desse estudo foi avaliar a ocorrência de parabenos e triclosan em ambientes de uma região subtropical, mais especificamente na Região Metropolitana de Curitiba (sul do Brasil) e avaliar possíveis efeitos desses compostos em ambientes aquáticos, através da avaliação de risco através do quociente de risco (QR). Foram coletadas amostras em 20 pontos em rios da Região Metropolitana de Curitiba, durante quatro campanhas. Para a extração dos compostos, foi utilizada a técnica de extração em fase sólida (SPE), com determinação por cromatografia gasosa acoplada à espectrometria de massas (GC-MS). Foram observadas elevadas concentrações de parabenos, especialmente MeP (máximo de 2875 ng L -1 ). Apesar das concentrações elevadas de parabenos a presença dos mesmos apresentou baixo risco para os organismos aquáticos. Quanto ao triclosan, observaram-se também elevadas concentrações (415 ng L -1 ), sugerindo mais uma vez que esses ambientes encontram-se impactados pela ação humana. O valor de QR permitiu avaliar que o triclosan apresentou um elevado risco para certos grupos de organismos.

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Effect of triclosan (TRN) on energy-linked functions of rat liver mitochondria

Cited by 72 publications

References 38 publications

Triclosan exposure, transformation, and human health effects

Triclosan exposure, transformation, and human health effects

Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissues

Occurrence and risk assessment of parabens and triclosan in surface waters of southern Brazil: a problem of emerging compounds in an emerging country

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