Effect of Tribulus terrestris in mercuric chloride-induced renal accumulation of mercury and nephrotoxicity in rat

Abstract

Mercury generates free radicals and subsequently increases oxidative stress, which leads to renal injury. Tribulus terrestris (TT) has good anti-inflammatory and antioxidant properties. Hydroalcoholic extract of different dose of TT was evaluated against mercuric chloride-induced nephrotoxicity. Rats ( n = 6) were treated with TT at doses of 100, 200, and 300 mg/kg. Drugs were administered orally for 7 days. Single dose of mercuric chloride (5 mg/kg, intraperitoneal) on the 5 th day caused significant elevation of blood urea nitrogen, serum creatinine, malondialdehyde, liver fatty acid binding protein, kidney injury molecule-1, and kidney mercury level and fall in glutathione, superoxide dismutase, glutathione peroxidase, and histopathological changes in disease control as compared to normal control group ( P < 0.001). Dose of TT 200 and 300 mg/kg significantly ( P < 0.001) prevented the renal injury, and mercury accumulation in kidney tissues significantly decreases in higher dose, i.e., 300 mg/kg as compared to control group. Our result indicates that the treatment of TT exerted significant protection against renal damage induced by mercuric chloride possibly due to its antioxidant and anti-inflammatory properties and by decreasing the renal accumulation of mercury.

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

“…HgCl 2 generates free radicals and subsequently increases oxidative stress, which leads to nephrotoxicity and accelerates hepatotoxicity [ 21 ]. This adverse effect of HgCl 2 could be eliminated by DPPD treatment probably because of its strong free radical scavenging activity through the electron(s) donation pathway, protecting cells from oxidation and necrosis [ 11 ].…”

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl4-Induced Liver Injury Model of Wistar Rats

“…T terrestris showed a protective kidney response in nephrotoxic rats. 33 M pruriens at the dose of 700 mg/kg b.wt show a protective response against arsenic-induced liver and kidney toxicity by reduced levels of kidney and liver enzymes. 34 A racemosus showed the kidney protective effect against alloxan induced diabetes rats.…”

The Effects of Tribulus Terrestris Extract and Endurance Training on Oxidative Stress and Apoptotic Markers in the Kidney Tissue of Rats, Poisoned with Arsenic

“…The results showed that TT5 and TT10 increased ATP levels and decreased renal MDA, PAB, and MGMT in rats, with a greater effect observed in the TT10 group compared with TT5. The main protective effect of TT against nephrotoxicity may be related to the antioxidative effects of this plant, namely inhibiting the release of calcium and Cyt-C by reducing blood nitrogen-urea (BUN) and creatinine, reducing KIM-1 and liver fatty acid-binding protein (L-FABP), and increasing GSH expression (reduced glutathione), catalase, and SOD in renal tubules, which improve oxidative phosphorylation and increase ATP in renal tissue (27). Activation of p38 mitogen-activated protein kinase (MAPK) also leads to activation of nuclear respiratory factor (NRF)1/2 that leads to increased expression of DNA repairing genes (28).…”