Effect of trehalose and melibiose on crystallization of amorphous paracetamol

Non-isothermal thermogravimetry as an accelerated tool for the shelf-life prediction of paracetamol formulations

“…Literature reports that the excipients can significantly alter the properties and functionalities of paracetamol. As examples, the presence of povidone could generate severe allergy [33], while excipients containing trehalose and melibiose affect the crystallization of the drug molecules [34]. The degradation of paracetamol can be influenced by several processes, such as peroxymonosulfate activation reactions [35] and catalytic actions of iron oxide nanostructures [36] or black TiO2 as photocatalysts [37].…”