Effect of treatment with diazepam or lithium and alcohol on psychomotor skills related to driving

Linnoila, Markku; Saario, I.; Maki, M

doi:10.1007/bf00558202

Cited by 106 publications

(23 citation statements)

References 7 publications

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“…The authors failed to indicate whether any relationship to serum lithium emerged. These findings confirmed prior reports of dysphoric mood change and slowed reaction time in normal subjects receiving lithium (3,4).…”

Section: Introductionsupporting

confidence: 82%

Lithium Effects on Normal Subjects

White¹,

Bohart²,

Whipple³

et al. 1979

Int Pharmacopsychiatry

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15 normal subjects took lithium carbonate for 10 days in dosage sufficient to attain plasma lithium concentrations in the range of 0.7-1.4 mEq/1. Periodic blood specimens were analyzed for both plasma and RBC lithium. Subjects completed Profile of Mood States questionnaires every other day, and listed side effects. Just prior to beginning and ending the lithium trial, 10 subjects completed three tests of psychomotor function. Results indicate that such a course of lithium in normals induces dysphoric mood change and psychomotor slowing, without significant relationship to either plasma or RBC lithium concentrations.

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Section: Introductionsupporting

confidence: 82%

Lithium Effects on Normal Subjects

White¹,

Bohart²,

Whipple³

et al. 1979

Int Pharmacopsychiatry

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“…The ability to discriminate CFF thresholds has been used as a measure of cortical visual processes (16). Especially, effects on CFF thresholds reflecting drowsiness and sedation have been observed more clearly after the ingestion of psychotropic drugs (14) than after alcohol (23). According to Gamberale et al (11) exposure to a xylene concentration of 12.3 pmolll (1,305 mg/m 3 ) for 70 min caused no measurable sedation when studied by CFF.…”

Section: Discussionmentioning

confidence: 99%

Effects of xylene and alcohol on vestibular and visual functions in man.

Savolainen¹,

Riihimäki²,

Vaheri³

et al. 1980

Scand J Work Environ Health

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“…While originally conceived as an explanation for selective-perception and attention phenomena, it has influenced many later information-processing approaches, in both psychopharmacological and non-psychopharmacological research. These models show many similarities to Broadbent's (1958) original (Broadbent, 1971;Linnoila, 1974;Bixler et al, 1975;Hindmarch, 1980;Broadbent, 1982;Wesnes et al, 1987). Another group of models is derived from Donders' pioneering studies of choice reaction time.…”

mentioning

confidence: 82%

Performance tests in human psychopharmacology (3): Construct validity and test interpretation

Parrott

1991

Human Psychopharmacology

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The content. criterion and face validity of human performance tests in psychopharmacology research were examined in an earlier paper. Most evidence on test meaning and interpretation, however, comprises construct validity. This is critically scrutinized here, through a brief analysis of human performance theory (Broadbent, Sanders, Sternberg), and taxonomies of human performance function (Fleishman, Holding). While much construct evidence is rather nebulous and untestable (non-disprovable), it is probably the most accurate representation of current views on performance assessment. Tests gradually fall out of favour (or) into favour, rather than being shown to be clearly invalid (or) valid. Factor analysis, and task discrimination, are, however, two procedures for placing test interpretation/meaning on a sounder empirical basis. Returning to the overall problem of how best to investigate test validity. several proposals are made. Further criterion information should be sought, in large-scale studies, designed specifically to compare the practical utility of different tests and test batteries. There needs to be greater atmosphere of critical debate on test meaning, in order to clarify the performance functions being assessed. Factor analysis and task discrimination procedures also need to be more widely employed. Lastly, although many tests can be seen as measures of 'information processing', the inference that they provide indices of 'real-life performance', can rarely be made on current evidence.

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Effect of treatment with diazepam or lithium and alcohol on psychomotor skills related to driving

Cited by 106 publications

References 7 publications

Lithium Effects on Normal Subjects

Lithium Effects on Normal Subjects

Effects of xylene and alcohol on vestibular and visual functions in man.

Performance tests in human psychopharmacology (3): Construct validity and test interpretation

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