Effect of trans-retinoic acid in the inhibition of cholesteatoma in guinea pigs

Antunes, Marcos Luiz; Fukuda, Yotaka; Penido, Norma de Oliveira; Ferreira, Rimarcs Gomes

doi:10.1016/s1808-8694(15)30751-5

Cited by 10 publications

(17 citation statements)

References 16 publications

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“…Cholesteatoma can be induced by injecting drugs into the tympanic bulla 1 , 12 – 16 . In the current study, cholesteatoma was induced by intratympanic injection via the tympanic membrane, in a model in which down-regulation of fibroblast action was expected due to mitomycin C. The cholesteatoma frequency in the control group was similar to previously published figures, i.e.…”

Section: Discussionsupporting

confidence: 89%

Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats

et al. 2013

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Section: Discussionsupporting

confidence: 89%

Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats

et al. 2013

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“…However, uncontrolled keratin formation by proliferating keratinocytes in the cholesteatoma matrix forms a vicious cycle in which the accumulated keratin debris overwhelms the self-cleaning mechanisms of the tympanic membrane, preventing clearance of newly formed keratin 26 . Since cholesteatoma is a hyperkeratotic disease with advanced keratinisation, vitamin A derivatives (which are effective in treating skin keratinisation disorders) have been used in experimental models to inhibit cholesteatoma formation 6 21 …”

Section: Discussionmentioning

confidence: 99%

Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation

et al. 2016

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“…Retinoic acid is an antiproliferativum (a growth-inhibiting agent) and has been shown to counter the formation of cholesteatoma relapses in animal experiments on guinea pigs. 50 In addition, the nowadays common practice to use collagen pads as interponates to soften the transition between the tympanic membrane and the head part of the prosthesis (Fig. 1b) seems to be in need of improvement in our view.…”

Section: Establishing a Mesoporous Silica-based Drug Release System Omentioning

confidence: 90%

Mesoporous silica films as a novel biomaterial: applications in the middle ear

et al. 2013

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In this tutorial review we present the process of the development of functional implants using mesoporous silica. The different steps from chemical synthesis and physicochemical characterization followed by in vitro testing in cell culture assays to clinically relevant in vivo animal studies are examined. Since the end of the 1990s, mesoporous silicas have been considered as biomaterials. Numerous investigations have demonstrated their non-toxic and biocompatible properties. These qualities in combination with the unique properties of high surface area and pore volume, uniform and tunable pore sizes and chemical modifiability are the reasons for the great scientific interest in this field. Here we show that besides bulk materials or mesoporous silica nanoparticles, mesoporous silica films are highly promising as coatings on medical prostheses or implants. We report on the development of functionalized mesoporous silica materials specifically for middle ear applications. Middle ear prostheses are used to restore the sound transmission through this air-filled cavity when the small bones of the middle air (the ossicular chain) have been destroyed by disease or by accidents. In addition to optimal restoration of sound transmission, this technique bears several challenges, e.g. an ongoing bacterial infection or the displacement of the prosthesis due to insufficient fixation. To improve the healing process, a mesoporous silica coating was established on ceramic middle ear prostheses, which then served as a base for further functionalizations. For example, the bone growth factor BMP2 was locally attached to the coating in order to improve the fixation of the prosthesis by forming a bony connection to the remainder of the ear bones. Further, an implant-based local drug delivery system for the antibiotic ciprofloxacin was developed with the aim of fighting bacterial infections. Further possibilities using mesoporous silica nanoparticles as part of a composite on an implant are briefly discussed. Key learning pointsThe way from clinical problems to improved implant materials: materials development, in vitro and in vivo testing. Establishment of mesoporous thin silica films on ceramic surfaces. Degradation of mesoporous silica films in physiological medium. Implant-carried mesoporous silica films as drug delivery systems. Implant-based delivery of biomolecules using mesoporous silica coatings.

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Effect of trans-retinoic acid in the inhibition of cholesteatoma in guinea pigs

Abstract: The local use of the trans-retinoic acid is effective in inhibiting the induced formation of cholesteatomas in guinea pigs.

Cited by 10 publications

References 16 publications

Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats

Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats

Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation

Mesoporous silica films as a novel biomaterial: applications in the middle ear

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