Effect of Tramadol on Rabbit Uterine Contractile Activity Induced in Late Pregnancy

Abstract

Effect of Tramadol infusion (5 mg/ml) on oxytocin-induced uterine contractile activity was studied in chronic experiment on female rabbits with different degrees of biological readiness for parturition. In case of sufficient biological readiness for parturition, Tramadol did not change the number of uterine contractions, but increased the amplitude and duration of each contraction against the background of increased creatine phosphate consumption by the myometrium. At the same time, Tramadol infusion to females without biological readiness for partirition suppressed induced uterine contractile activity by reducing the amplitude of each uterine contraction.

Analgesia during Parturition in Domestic Animals: Perspectives and Controversies on Its Use

“…In an effort to prevent negative effects on myometrial contractility and depressor effects in the neonate, some authors have proposed the use of atypical opioids such as tramadol, which work through inhibiting serotonin and norepinephrine reuptake in sensitive fibers [ 65 ], as an option that does not alter uterine activity. A study by Yakovleva et al [ 66 ] evaluated tramadol’s effect on uterine contractile activity in chinchillas ( Oryctolagus cuniculus ) at 28 days of gestation. Animals received 1 U of oxytocin by IV to initiate labor, and then 1 mL of tramadol in infusion at a concentration of 5 mg/mL, 10 min later.…”

Aglepristone Use for Termination of Pregnancy in Rabbits

“…Gebelik boyunca myometrium metabolik, fonksiyonel ve yapısal olarak değişir ve oksitosine duyarsız hale gelir. Doğumdan hemen önce oksitosin reseptörlerinin farklılaşması [18] ve sayısının artması ile oksitosine karşı yeniden duyarlılık oluşur [19]. Oksitosin bu dönemde PGF2α, PGE2 ve lökotrienlerin üretimini artırmak suretiyle doğumun başlamasında önemli rol almaktadır [18].…”