Effect of Total Scar Burden on Contrast-Enhanced Magnetic Resonance Imaging on Response to Cardiac Resynchronization Therapy

Ypenburg, Claudia; Roes, Stijntje D.; Bleeker, Gabe B.; Kaandorp, Theodorus A.M.; Roos, Albert de; Schalij, Martin J.; Wall, Ernst E. van der; Bax, Jeroen J.

doi:10.1016/j.amjcard.2006.09.115

Cited by 252 publications

(163 citation statements)

References 13 publications

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“…Our results indicate decreased beneficial effect of LV or BIV pacing in animals with extensive MI. These results are consistent with various clinical results indicating that the beneficial effect of CRT is highly dependent on the scar burden and is lost when the scar burden passes a certain limit [31,32]. A recent study in a dog model indicated, however, a clear beneficial effect of CRT in the setting of ,20% scar burden [33].…”

Section: Discussionsupporting

confidence: 81%

Speckle-Tracking Echocardiography Elucidates the Effect of Pacing Site on Left Ventricular Synchronization in the Normal and Infarcted Rat Myocardium

et al. 2013

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Section: Discussionsupporting

confidence: 81%

Speckle-Tracking Echocardiography Elucidates the Effect of Pacing Site on Left Ventricular Synchronization in the Normal and Infarcted Rat Myocardium

et al. 2013

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“…Global scar burden has been shown to be inversely proportional to LV reverse remodeling amongst both ischemics [41], non-ischemics [42], and mixed populations [43–45]. Functional improvement [41,42,46] and survival [47] are also inversely proportional to scar burden.…”

Section: Tissue Characterizationmentioning

confidence: 99%

Optimal site selection and image fusion guidance technology to facilitate cardiac resynchronization therapy

Sieniewicz

Gould

Porter

et al. 2018

Expert Review of Medical Devices

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Introduction: Cardiac resynchronization therapy (CRT) has emerged as one of the few effective treatments for heart failure. However, up to 50% of patients derive no benefit. Suboptimal left ventricle (LV) lead position is a potential cause of poor outcomes while targeted lead deployment has been associated with enhanced response rates. Image-fusion guidance systems represent a novel approach to CRT delivery, allowing physicians to both accurately track and target a specific location during LV lead deployment.Areas covered: This review will provide a comprehensive evaluation of how to define the optimal pacing site. We will evaluate the evidence for delivering targeted LV stimulation at sites displaying favorable viability or advantageous mechanical or electrical properties. Finally, we will evaluate several emerging image-fusion guidance systems which aim to facilitate optimal site selection during CRT.Expert commentary: Targeted LV lead deployment is associated with reductions in morbidity and mortality. Assessment of tissue characterization and electrical latency are critical and can be achieved in a number of ways. Ultimately, the constraints of coronary sinus anatomy have forced the exploration of novel means of delivering CRT including endocardial pacing which hold promise for the future of CRT delivery.

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“…In those with severe LV dysfunction, the percent of patients with detectable scar by Cardiac magnetic resonance (CMR) imaging ranged 12-100%, depending on the underlying cause of heart failure [12]. Both White et al [13] and Ypenburg et al [14] reported that total scar burden, determined by CMR is linearly related to relative changes in LVESV after 6 months of CRT, thus the greater amount of viable myocardium present, the larger reverse remodeling. Speckle tracking imaging, which is an angle independent approach to strain analysis, has enabled the development of new parameters to assess both global and segmental function [15].…”

Section: Discussionmentioning

confidence: 99%

A new score system for predicting response to cardiac resynchronization therapy

et al. 2015

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06%). A 4-point score system was generated based on tricuspid annular plane systolic excursion (TAPSE), longitudinal strain (LS), and complete left bundle branch block (CLBBB)combined with a wide QRS duration (QRSd). The sensitivity and specificity for prediction of a positive response to CRT at a score > 2 were 0.823 and 0.850, respectively (AUC: 0.92295% CI 0.691-0.916, p< 0.001). Conclusions: A patient selection score system based on the integration of TAPSE, LS and CLBBB combined with a wide QRSd can help to predict positive response to CRT effectively and reliably. (Cardiol J 2015; 22, 2: 179-187)

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Effect of Total Scar Burden on Contrast-Enhanced Magnetic Resonance Imaging on Response to Cardiac Resynchronization Therapy

Cited by 252 publications

References 13 publications

Speckle-Tracking Echocardiography Elucidates the Effect of Pacing Site on Left Ventricular Synchronization in the Normal and Infarcted Rat Myocardium

Speckle-Tracking Echocardiography Elucidates the Effect of Pacing Site on Left Ventricular Synchronization in the Normal and Infarcted Rat Myocardium

Optimal site selection and image fusion guidance technology to facilitate cardiac resynchronization therapy

A new score system for predicting response to cardiac resynchronization therapy

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