A new score system for predicting response to cardiac resynchronization therapy

Kang, Yu; Cheng, Leilei; Cui, Jie; Liu, Lin; Qin, Shengmei; Su, Yangang; Mao, Jialiang; Gong, Xue; Chen, Haiyan; Pan, Cuizhen; Shen, Xuedong; He, Ben; Shu, Xianhong

doi:10.5603/cj.a2014.0089

Cited by 15 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kang Y et al [21] observed, that longitudinal strain and LBBB combined with a wide QRS can help to predict positive response to CRT effectively and reliably. In another study, none of the longitudinal strain indices was different between echocardiographic responders and nonresponders to CRT [22].…”

Section: Discussionmentioning

confidence: 99%

Związek zmian regionalnego odkształcenia podłużnego miokardium z odpowiedzią na terapię resynchronizującą serca u pacjentów z dysfunkcją skurczową lewej komory i blokiem lewej odnogi pęczka Hisa

Lisowska

Ptaszyńska‐Kopczyńska

Marcinkiewicz-Siemion

et al. 2018

Folia Cardiologica

View full text Add to dashboard Cite

The relationship of regional longitudinal strain changes and response to cardiac resynchronization therapy in patients with left ventricular systolic dysfunction and left bundle branch blockZwiązek zmian regionalnego odkształcenia podłużnego miokardium z odpowiedzią na terapię resynchronizującą serca u pacjentów z dysfunkcją skurczową lewej komory i blokiem lewej odnogi pęczka Hisa Abstract Introduction. Strain and strain rate (SR) are techniques, which provide local information on myocardial deformation. The aim of the study was to assess the usefulness of strain and SR measurement in cardiac resynchronization therapy (CRT) response in chronic heart failure (CHF) patients.Materials and methods. The study included 35 CHF patients with QRS complex duration ≥ 120ms with LBBB morphology. Biochemical and clinical parameters were assessed before and after six months of CRT. TTE classical and tissue Doppler echocardiography parameters (longitudinal peak systolic strain -LPS and SR for basal segment of intraventricular septum and lateral wall) were evaluated.Results. Twenty-two patients (62.8%) benefited from CRT (the responders) and revealed improvement in septal and lateral LPS in the 6-month observation [-7.1 (-5.2--11.1) vs -12.1 (-8.7--14)%, p = 0.002; -10.4 (-6.1--17.6) vs -13.8 (-8.9 --17.8)%, p = 0.03; respectively]. Six months after CRT, the responders were characterised by higher increase in septal LPS comparing to the nonresponders (-4.6 ± 6.1 vs -2.4 ± 3.9%, p = 0.045). Septal LPS changes correlated positively with baseline cardiopulmonary exercise testing (CPET) parameters: peak oxygen uptake (r = 0.6, p = 0.004), peak carbon dioxide excretion (r = 0.62, p = 0.002) and negatively with VE/VCO2 slope (r = -0.5, p = 0.037).Conclusions. LV regional LPS appears to be a good parameter reflecting the improvement of clinical status in patients treated with CRT. The responders had better improvement of septal LPS, therefore positive response to this therapy may be related to the improvement of septal contractility.

show abstract

Section: Discussionmentioning

confidence: 99%

Związek zmian regionalnego odkształcenia podłużnego miokardium z odpowiedzią na terapię resynchronizującą serca u pacjentów z dysfunkcją skurczową lewej komory i blokiem lewej odnogi pęczka Hisa

Lisowska

Ptaszyńska‐Kopczyńska

Marcinkiewicz-Siemion

et al. 2018

Folia Cardiologica

View full text Add to dashboard Cite

show abstract

“…Based on the Japan Cardiac Device Treatment Registry (JCDTR) database [21], the proportion of HF patients with NICM is as great as 70%. Based on our previous studies, patients with NICM were also common (> 60%)in China [6,22].…”

Section: The Published Scoresmentioning

confidence: 93%

A novel risk model for mortality and hospitalization following cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy: the alpha-score

Yang

Liu

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: Non-ischemic cardiomyopathy (NICM) has been associated with a better left ventricle reverse remodeling response and improved clinical outcomes after cardiac resynchronization therapy (CRT). The aims of our study were to identify the predictors of mortality and heart failure hospitalization in patients treated with CRT and design a risk score for prognosis. Methods: A cohort of 422 consecutive NICM patients with CRT was retrospectively enrolled between January 2010 and December 2017. The primary endpoint was all-cause mortality and heart transplantation. Results: In a multivariate analysis, the predictors of all-cause death were left atrial diameter [Hazard ratio (HR): 1.

show abstract

“…9,10,21) This finding is also practical in clinical situations because a 12-lead ECG is available for every patient before CRT and provides a reasonable sensitivity and specificity in predicting the response to CRT. Although some other tools are also available for predicting outcome after CRT, such as echocardiography including the tissue Doppler technique, 22) cardiovascular magnetic resonance, 23,24) and nomograms, 3,22,25,26) QRS duration and complete LBBB on a surface ECG are still the proven independent predictors for the response after CRT. 3,27) In the present study, the shortest, longest, and average QRS durations were significantly different.…”

Section: Discussionmentioning

confidence: 99%

The Shortest QRS Duration of an Electrocardiogram Might Be an Optimal Electrocardiographic Predictor for Response to Cardiac Resynchronization Therapy

2017

View full text Add to dashboard Cite

SummaryQRS duration has been associated with the response to cardiac resynchronization therapy (CRT). However, the methods for defining QRS duration to predict the outcome of CRT have discrepancies in previous reports. The aim of this study was to determine an optimal measurement of QRS duration to predict the response to CRT.Sixty-one patients who received CRT were analyzed. All patients had class III-IV heart failure, left ventricular ejection fraction not more than 35%, and complete left bundle branch block. The shortest, longest, and average QRS durations from the 12 leads of each electrocardiogram (ECG) were measured. The responses to CRT were determined using the changes in echocardiography after 6 months. Thirty-five (57.4%) patients were responders and 26 (42.6%) patients were non-responders. The pre-procedure shortest, average, and longest QRS durations and the QRS shortening (ΔQRS) of the shortest QRS duration were significantly associated with the response to CRT in a univariate logistic regression analysis (P = 0.002, P = 0.03, P = 0.04 and P = 0.04, respectively). Based on the measurement of the area under curve of the receiver operating characteristic curve, only the pre-procedure shortest QRS duration and the ΔQRS of the shortest QRS duration showed significant discrimination for the response to CRT (P = 0.002 and P = 0.038, respectively). Multivariable logistic regression showed the pre-procedure shortest QRS duration is an independent predictor for the response to CRT.The shortest QRS duration from the 12 leads of the electrocardiogram might be an optimal measurement to predict the response to CRT. (Int Heart J 2017; 58: 530-535) Key words: Heart failure C ardiac resynchronization therapy (CRT) is a wellknown procedure for improving left ventricular function via reverse remodeling in patients with heart failure.1) The QRS durations before implantation and at follow-up may predict the patient's response to CRT, especially in the presence of left bundle branch block (LBBB).2-8) However, the QRS durations are usually different and diverse among the 12-lead electrocardiogram (ECG). 9) Additionally, in previous reports, the methods to define the QRS duration in predicting a CRT patient's outcome have discrepancies and lack standardization of QRS duration measurement.10) Many different methods for QRS duration measurement have been used in previous studies, including the QRS duration of one selected lead, 11,12) the longest QRS duration, 13) the average QRS duration of 12 leads, 14) and undefined. 6,15,16) International guidelines for heart failure management also have not recommended a preferred standard measurement technique for QRS duration for CRT.2,10,17,18) Lack of standard measurement in the QRS duration might have a significant influence on the conclusions of different studies.10) Thus, this is the crucial reason why the recommended QRS duration for CRT implantation was different and variable in previous reports. However, the decision-making for suggesting that a patient receive a CRT implanta...

show abstract

A new score system for predicting response to cardiac resynchronization therapy

Cited by 15 publications

References 23 publications

Związek zmian regionalnego odkształcenia podłużnego miokardium z odpowiedzią na terapię resynchronizującą serca u pacjentów z dysfunkcją skurczową lewej komory i blokiem lewej odnogi pęczka Hisa

Związek zmian regionalnego odkształcenia podłużnego miokardium z odpowiedzią na terapię resynchronizującą serca u pacjentów z dysfunkcją skurczową lewej komory i blokiem lewej odnogi pęczka Hisa

A novel risk model for mortality and hospitalization following cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy: the alpha-score

The Shortest QRS Duration of an Electrocardiogram Might Be an Optimal Electrocardiographic Predictor for Response to Cardiac Resynchronization Therapy

Contact Info

Product

Resources

About