Effect of topical tubercidin on basal cell carcinomas and actinic keratoses

Burgess, Gordon H.; Bloch, Alexander; Stoll, Howard L.; Milgrom, Halena; Helm, Frederick; Klein, Edmund

doi:10.1002/1097-0142(197408)34:2<250::aid-cncr2820340204>3.0.co;2-x

Cited by 13 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tubercidin (7-deaza-adenosine) is a pyrrolopyrimidine nucleoside. In a 0-5% concentration in petrolatum it was found to be effective in the treatment of eight solitary nodular basal cell carcinomas, but ineffective in the treatment of solar keratoses (Burgess et al, 1974). It produced a severe infiammatory reaction resulting in ulceration ofthe basal cell carcinomas with healing in 8 weeks and no recurrence after i\ years of follow-up.…”

Section: Discussionmentioning

confidence: 98%

The use of the hairless mouse to develop topical cytostatic combination chemotherapy

1984

View full text Add to dashboard Cite

Summary In a search for more topically active anti‐proliferative agents for potential use in psoriasis and in skin cancer, certain putative cytostatic drugs have been investigated in hairless mouse epithelium. We found that 5% concentrations of razoxane, tubercidin and podophyllin and 0.2% concentration of vincristine produced a significant local inhibition of DNA synthesis. These drugs were also evaluated in combination with either 0.25% cycloheximide or 5% 5‐fluorouracil, two compounds with established topical cytostatic action. Enhanced effects were noted from combining tubercidin, vincristine or razoxane with cycloheximide and from combining tubercidin with 5‐fluorouracil. In view of the inflammatory side‐effects of cycloheximide, this drug was combined with 0.001% and 0.005% betamethasone 17‐valerate and the combination found to be significantly more effective than cither drug applied alone. There is potential for clinical investigation into the topical use of these drugs both alone and in combination with other agents.

show abstract

Section: Discussionmentioning

confidence: 98%

The use of the hairless mouse to develop topical cytostatic combination chemotherapy

1984

View full text Add to dashboard Cite

show abstract

“…Tubercidin, toyocamycin, sangivamycin and derivatives are bacteria-derived adenosine analogues with different effects on RNA and DNA, protein kinase C, microtubules, and nucleophosmin (NPM1) [ 214 , 215 , 216 , 217 , 218 ]. These have been used in small clinical trials, in the case of tubercidin with clinical efficacy [ 219 , 220 , 221 , 222 , 223 , 224 ]. Importantly, differential resistance to these nucleoside analogues has been described in vitro [ 225 ].…”

Section: Overview On the Pharmacodynamics Of Nucleobase And Nucleomentioning

confidence: 99%

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

Tsesmetzis

Paulin

Rudd

et al. 2018

Cancers

101

View full text Add to dashboard Cite

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs that, starting from the small field of paediatric oncology, in combination with other chemotherapeutics, have revolutionised clinical oncology and transformed cancer into a curable disease. However, even though combination chemotherapy, together with radiation, surgery and immunotherapy, can nowadays cure almost all types of cancer, we still fail to achieve this for a substantial proportion of patients. The understanding of differences in metabolism, pharmacokinetics, pharmacodynamics, and tumour biology between patients that can be cured and patients that cannot, builds the scientific basis for rational therapy improvements. Here, we summarise current knowledge of how tumour-specific and patient-specific factors can dictate resistance to nucleobase/nucleoside analogues, and which strategies of re-sensitisation exist. We revisit well-established hurdles to treatment efficacy, like the blood-brain barrier and reduced deoxycytidine kinase activity, but will also discuss the role of novel resistance factors, such as SAMHD1. A comprehensive appreciation of the complex mechanisms that underpin the failure of chemotherapy will hopefully inform future strategies of personalised medicine.

show abstract

Molecular bases for the action and selectivity of nucleoside antibiotics

Carrasco¹,

Vázquez²

1984

Medicinal Research Reviews

View full text Add to dashboard Cite

Effect of topical tubercidin on basal cell carcinomas and actinic keratoses

Cited by 13 publications

References 7 publications

The use of the hairless mouse to develop topical cytostatic combination chemotherapy

The use of the hairless mouse to develop topical cytostatic combination chemotherapy

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

Molecular bases for the action and selectivity of nucleoside antibiotics

Contact Info

Product

Resources

About