1984
DOI: 10.1111/j.1365-2230.1984.tb00773.x
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The use of the hairless mouse to develop topical cytostatic combination chemotherapy

Abstract: Summary In a search for more topically active anti‐proliferative agents for potential use in psoriasis and in skin cancer, certain putative cytostatic drugs have been investigated in hairless mouse epithelium. We found that 5% concentrations of razoxane, tubercidin and podophyllin and 0.2% concentration of vincristine produced a significant local inhibition of DNA synthesis. These drugs were also evaluated in combination with either 0.25% cycloheximide or 5% 5‐fluorouracil, two compounds with established topic… Show more

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