Effect of topical hyaluronic acid on experimental cholesteatoma

White, Steven J.; Wright, Charles G.; Robinson, Karen S.; Meyerhoff, William L.

doi:10.1016/0196-0709(95)90059-4

Cited by 16 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Local and sustained release of fibroblast growth factor enhanced wound healing in EAs [19]. Tissue glues have been used in fistula repair and recurrent fistula [5][6][7][8][9][10][11][12], but they have not been used simultaneously with PA prophylactically to prevent esophageal leakages.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The healing effects of tissue glues and healing agent locally applied on esophageal anastomoses

Yurtçu

Arbağ

Toy

et al. 2010

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Natrium hyaluronate (NH) is a rather useful healing agent in several areas such as in the healing of tympanic membrane perforation, after cholesteatoma surgery for reconstruction of the middle ear, and for acute traumatic tympanic membrane perforation [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

The healing effects of tissue glues and healing agent locally applied on esophageal anastomoses

Yurtçu

Arbağ

Toy

et al. 2010

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

“…Serial applications of concentrated hyaluronan accelerated healing and decreased scar tissue formation. 18 An agent such as NH, which has been shown to reduce connective tissue overgrowth in healing wounds, might be expected to alter the pyeloplasty healing process in the rabbit model and thereby provide additional insight into the pathogenesis of PUJOs. AI, CI, GTA, GTFM, CD, re-epithelialization (R), neovascularization (N), and PTR in anastomosis lines could be considered reliable and objective anastomoses markers in scar tissue formation.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomoses

Yurtçu

Baba

2012

Renal Failure

View full text Add to dashboard Cite

Objectives: This study aimed to investigate the effect of natrium hyaluronate (NH) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA). Materials and methods: Eighteen rabbits were divided equally into three groups: surgical (S), sham (Sh), and NH. A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were injected with saline (Sh group) and NH (NH group) into anastomoses lines after the surgical procedure. The S group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelialization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later. Main findings: There were no significant differences in the GTFM scores in the S group compared with those in the NH group. In the NH group, N scores were higher than they were in the S group. Re-epithelialization in the NH group was higher than it was in the S group. Principle conclusions: NH did not decrease fibrosis, but increased important parameters in wound healing such as neovascularization and re-epithelialization in an experimental model of PUA in rabbits.

show abstract

“…145 Most clinical applications use commercial preparations of HA 71 i.e., Healon (Pharmacia) is used in ophthalmology at HA 0.2% while topical applications of gels containing HA in drugs (i.e., Solaraze) can go up to 2.5% but most typical HA concentrations are in the range of 0.2-1.5%. 156 Delivery of HA in wounds in liquid form, instead of dressings or scaffolds, may accelerate regeneration. 137 This follows the general accepted theory that wet healing is faster and beneficial in skin.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Bioengineering the Skin–Implant Interface: The Use of Regenerative Therapies in Implanted Devices

Peramo

Marcelo

2010

Ann Biomed Eng

View full text Add to dashboard Cite

This discussion and review article focuses on the possible use of regenerative techniques applied to the interfaces between skin and medical implants. As is widely known, the area of contact between an implant and the skin--the skin-implant interface--is prone to recurrent and persistent problems originated from the lack of integration between the material of the implant and the skin. Producing a long-term successful biointerface between skin and the implanted device is still an unsolved problem. These complications have prevented the development of advanced prosthetics and the evolution of biointegrated devices with new technologies. While previous techniques addressing these issues have relied mostly on the coating of the implants or the modification of the topology of the devices, recent in vitro developed techniques have shown that is possible to introduce biocompatible and possibly regenerative materials at the skin-device interface. These techniques have also shown that the process of delivering the materials has biological effects on the skin surrounding the implant, thus converting bioinert into bioactive, dynamic interfaces. Given that the best clinical outcome is the long-term stabilization and integration of the soft tissue around the implant, this article presents the basis for the selection of regenerative materials and therapies for long-term use at the skin-device interface, with focus on the use of natural biopolymers and skin cell transplantation.

show abstract

Effect of topical hyaluronic acid on experimental cholesteatoma

Cited by 16 publications

References 24 publications

The healing effects of tissue glues and healing agent locally applied on esophageal anastomoses

The healing effects of tissue glues and healing agent locally applied on esophageal anastomoses

The Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomoses

Bioengineering the Skin–Implant Interface: The Use of Regenerative Therapies in Implanted Devices

Contact Info

Product

Resources

About