Effect of Topical Application of Copper in Combination with Fluoride in Drinking Water on Experimental Caries in Rats

Abstract

A cariostatic effect of copper sulfate was observed in rats in a recent study by Afseth et al. In the present study, effects of the combination of topically applied copper with fluoride in the drinking water were determined. Groups of animals receiving a combination of copper and fluoride developed significantly less caries than the groups given either substance alone at the corresponding concentrations. Reduced numbers of Streptococcus mutans were isolated from animals receiving Cu treatment. This reduction was most pronounced in rats treated with elevated Cu concentrations alone and in combination with F.

The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats

“…Administration of several substances, including al., 1983a). Equally, phenomena associated with remineralization fluoride (Konig et al, 1965;Afseth et al, 1984), shortly after tooth are primarily influenced locally. Clearly, frequency and pattern of eruption leads to the elimination of hypomineralized areas.…”

Remineralization and Demineralization in situ from a Triclosan/Co-polymer/Fluoride Dentifrice

“…Other anti-plaque agents have also shown anti-caries effects. Luoma et al (1978) and Dolles and Gjermo (1980) showed that chlorhexidine improved the anti-caries effects of fluoride in humans, and Afseth et al (1984) reported that a combination of fluoride and copper salts provided additive anti-caries effects in rats.…”

Effect of Low-Level Fluoride and Caries Incidence in Rats (Short Communication)

“…Although there are numerous studies in rats on the effect of fluoride in caries reduction, the majority have utilized large concentrations of fluoride [Larson et al, 1976;Tinanoff and Camosci, 1984;Afseth et al, 1984]. Generally, the concentrations are greater than that recommended for human consumption; conse quently, the development of an adequate animal model has been lacking.…”