Effect of Topical Application of Vitamins and Some Other Chemicals on the Healing of Wounds

Williams, Robert H.; Bissell, Grosvenor W.

doi:10.1001/archsurg.1944.01230020233002

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…The experimental protocols were considerably different than those of Brush et al. In Williams and Bissell's experiments, there were three wounds of progressively greater depth, each across the back. The chemicals were applied each day.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 94%

“…X‐rays were also used from the 1920s to the 1950s to treat a broad range of infectious conditions, some of which included dermal wounding. Finally, other investigators selected a broad range of commonly available agents, many of which had been used in the treatment of burns, especially in industrial settings to be tested within an experimental framework using guinea pigs or rats . The present section addresses such experimental evaluations.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

“…Williams and Bissell conducted four experiments in male and female rats to assess whether a broad range of vitamins and essential oils enhanced the dermal wound healing process. The experimental protocols were considerably different than those of Brush et al.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

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Section: Early Product Testing and Applicationsmentioning

confidence: 94%

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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“…Various agents have been used to expedite the healing process which is either proceeding normally or delayed [8][9][10][11][12][13][14]. Traditional medicine involves the use of medicinal herbs as they are easily accessible and cheap.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Pathak

Shenoy

Kiran

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to assess the effect of ethanolic extract of Cyanotis cristata leaves when applied topically on healing of wound in Wistar rats. Methods:C. cristata leaves were evaluated for its effect on healing of wound in three models, namely, incision, excision, and burn wound. Each model included five groups, each consisting of 6 rats. The five groups were as follows: Group I rats (control and ointment base), Group II rats (standard and silver sulfadiazine), and Group III, Group IV, Group V (treated with C. cristata extract ointment of 0.5%, 1%, and 2%, respectively). Variables evaluated included breaking strength in incision wound while it was contraction rate and epithelialization in excision and burn wound. One-way analysis of variance and Tukey's post hoc test was used to analyze data. Result:In incision wound, breaking strength in test group was significantly increased (p<0.001) as compared to control. In excision and burn wound of test group, time to epithelialization and contraction rate was significantly decreased (p<0.001). The granulation tissue from excision and burn wound showed increased collagen and less inflammatory cells in test groups in comparison to the control. Conclusion:The ethanolic extract of leaves of C. cristata, when applied topically, enhanced wound strength and accelerated healing of incision, excision, and burn wounds in rats.

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Evaluation of Wounds of the Rabbit Cornea Treated With Calsulfhydryl (Hydrosulphosol)

Rocknem¹

1953

Archives of Ophthalmology

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Effect of Topical Application of Vitamins and Some Other Chemicals on the Healing of Wounds

Cited by 7 publications

References 9 publications

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Evaluation of Wounds of the Rabbit Cornea Treated With Calsulfhydryl (Hydrosulphosol)

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