Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice

Singh, Gurwinder Kaur a/p Gurcharan; Utami, Novi Vicahyani; Usman, Hermin Aminah

doi:10.15850/amj.v1n1.289

Cited by 16 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on research by Miladiyah and Prabowo in 2012, it was stated that the ethanol extract of binahong leaves in concentrations of 20% and 40% was effective in healing 2 cm incision wounds in guinea pigs (Miladiyah & Prabowo, 2012). The same thing was done by Singh, et al in 2014 showed that topical administration of binahong leaf paste showed better results in healing 1 cm² incisional wounds in mice (Musmuscularis) (Gurcharan Singh et al, 2014). The results of research conducted by Violante, et al 2020 stated that the flavonoids in the hydroethanol extract of dried Fridericia chica leaves showed good antibacterial activity against Gram-negative and Gram-positive bacteria including Streptococcus pyogenes, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus, and Salmonella typhimurium (Violante et al, 2021).…”

Section: Introductionmentioning

confidence: 89%

BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE

Baso,

Azizah,

Rosyidah

et al. 2023

IMHSJ

View full text Add to dashboard Cite

Background: Postpartum infections are the top 4 main causes of the high maternal mortality rate in Indonesia at 2022 of 183 per 100,000 live births. Efforts to prevent complications due to infection of puerperal suture wounds with pharmacological therapy using antibiotics and antiseptics, as well as non-pharmacological ones using plant extracts. Binahong is believed to contain flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids, which are especially useful in healing wound infections. The aim of the study was to determine the effectiveness of infusion of binahong leaves (Anredera cordifolia (Tenore) Steenis) on the healing of suture wound infections in rats (Rattus norvegicus) experimental animals. Method: The research method was a true-experimental posttest only control group design, the study was conducted from June to August 2023 at the Microbiology and Pharmacology Laboratory of Muhammadiyah Sidoarjo University, the research variables were binahong leaf infusion and healing of suture infection, assessment and data collection using the REEDA scale instrument, statistical analysis with the one-way ANOVA, and post-hoc follow-up tests. Result: The results showed p <0.05, so there was a significant effect of giving binahong leaf infusion on the healing of suture wound infections. In terms of the difference in the mean value and the results of the post-hoc significant difference test, it appears that the 5% binahong leaf infusion group showed the most effective results in healing suture wound infections and was significantly different from the negative control group with less effective healing of suture infections. Conclusion : This is in line with research that states that the group given a 5% concentration of binahong extract was more effective than the group with a higher concentration. Thus, administration of a 5% concentration of binahong leaf infusion can be an alternative for healing suture wound infections due to the important content in it in the form of flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids. Further research is needed with lower concentrations of binahong leaf infusion to find out the minimum concentration that can have a good effect on the convalescence of suture wound infections.

show abstract

Section: Introductionmentioning

confidence: 89%

BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE

Baso,

Azizah,

Rosyidah

et al. 2023

IMHSJ

View full text Add to dashboard Cite

show abstract

“…Picture histopathology shows that the on-base group is visible cell fibroblast accompanied with fiber less collagen solid, different with group nanogels extract binahong leaf 3% showing many cells formed fibroblasts with accompanied fiber dense collagen. This can be caused by the phytochemicals content on the binahong leaf, flavonoids and saponins increase the proliferation of fibroblasts and stimulate the collagen formation on the proliferation phase, which can speed up wound healing [21,22].…”

Section: Osteoblastmentioning

confidence: 99%

Wound Healing Activity of Binahong Leaf Extract Nanogel on Oral Tissues

HANAFIAH,

SATRIA,

HARAHAP

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

Objective: The objective of the present study is to formulate and evaluate a topical gel containing minoxidil and tofacitinib citrate for alopecia areata. Methods: Forty-eight rat males were given treatment using 3% binahong leaf extract nanogel (twelve rats given palatal wound, twelve rats mandibular tooth extraction) and nanogel base (same with the amount used to extract). On palatal wounds, as many as four rats were in euthanasia on days third, seven, and fourteen for each group treatment. Whereas on the extraction groups, four rats were in euthanasia on days seventh, fourteen, and twenty-eight. palatal tissue and alveolar bone were taken, and fibroblasts as well as osteoblasts were observed using the coloring Hematoxylin-eosin. Results: Data revealed there were significant differences in the number of fibroblasts in each treatment between day three and seven (p<0.05), between day seven and fourteen (p<0.05), and there were significant differences in the number of osteoblasts in each treatment for 3 periods (p<0.05). Conclusion: Application of binahong leaf extract nanogel on palatal wound increased fibroblast proliferation and on post-extraction socket increased the number osteoblasts indicating better wound healing compared to control.

show abstract

“…In addition to having an antimicrobial effect, the active compound content of binahong leaves can also play a role in the tissue healing process because when used in certain doses it is not toxic and has a role as an antioxidant, anti-inflammatory, and antibacterial so that it can be used in the wound healing process [30]. Saponin compounds can increase monocyte proliferation thereby helping to increase the number of macrophages that will secrete growth factor TGF-β1 which will play a role in various phases of wound healing [31,32]. The content of tannins and triterpenoids which act as antibacterial also acts as an astringent in wounds and helps in the differentiation process of myofibroblasts [33,34].…”

Section: Calculation Of Ic 50 Valuementioning

confidence: 99%

Antibacterial activity, cytotoxicity, and phytochemicals screenings of binahong ( Anredera cordifolia (Ten.) steenis) leaf extract

Sugiaman,

Pranata,

Susila

et al. 2024

J Adv Pharm Educ Res

View full text Add to dashboard Cite

show abstract

Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice

Cited by 16 publications

References 9 publications

BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE

BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE

Wound Healing Activity of Binahong Leaf Extract Nanogel on Oral Tissues

Antibacterial activity, cytotoxicity, and phytochemicals screenings of binahong ( Anredera cordifolia (Ten.) steenis) leaf extract

Contact Info

Product

Resources

About