Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate

Levine, David G.; Epstein, Kira L.; Neelis, Dana A.; Ross, Michael W.

doi:10.2460/ajvr.70.11.1323

Cited by 39 publications

(26 citation statements)

References 10 publications

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“…This approach combines 2 methods, each previously found to limit systemic release of antibiotic to negligible levels, while concentrating drug within the metacapophalangeal joint . The volume perfused for IVRLP in our study (60 mL) has been found to produce high antimicrobial levels in synovial fluid, and is consistent with current clinical applications . Nonetheless, the lack of influence of IVRLP on local bioburden in our study justifies further investigation into pressures and volumes required to optimize wound bed perfusion.…”

Section: Discussionsupporting

confidence: 78%

Influence of intravenous regional limb perfusion with amikacin sulfate onStaphylococcus aureusbioburden in distal limb wounds in horses

et al. 2017

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Section: Discussionsupporting

confidence: 78%

Influence of intravenous regional limb perfusion with amikacin sulfate onStaphylococcus aureusbioburden in distal limb wounds in horses

et al. 2017

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“…Phlebitis is the most commonly reported complication with IVRLP, particularly with repeat IVRLP. 10,35 In addition, some pharmaceuticals result in vasculitis. 2 None of the 12 perfusions resulted in clinical signs of phlebitis or vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Morphine Synovial Fluid Concentrations After Intravenous Regional Limb Perfusion in Standing Horses

et al. 2015

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“…Repeated daily venipuncture with a small-gauge needle was not associated with serious adverse effects, and topical anti-inflammatory drugs 18 or intraperfusate dimethylsulfoxide 1 were not used. Placement of indwelling IV catheters for A-RLP has been reported clinically 1 and recently evaluated.…”

Section: Discussionmentioning

confidence: 99%

Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

Rubio‐Martínez

Elmas²,

Black³

et al. 2012

javma

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Objective—To describe the clinical use of regional limb perfusion with antimicrobials (A-RLP), complications, and outcome in a large series of patients. Design—Retrospective case series. Animals—174 horses. Procedures—Medical records of horses treated with A-RLP between 1999 and 2009 were reviewed. Signalment, primary complaint, horse use, etiology, duration of clinical signs, previous treatment, structures involved, concurrent conditions, A-RLP characteristics, additional treatments, complications, and outcome were recorded. At long-term follow-up, 2 outcomes were investigated: survival rate and return to previous use at the same or higher level. Univariate and multivariate logistic regression analyses were conducted. Results—Group 1 (96 horses) included septic synovitis. Group 2 (50 horses) included extrasynovial lacerations (23 horses) and fresh, minimally contaminated intrasynovial lacerations without evidence of established synovial infection (27 horses). Group 3 (28 horses) included miscellaneous other conditions. Only minor complications were reported in 12.26% of horses that received IV (n = 155) and 33% of horses that received intraosseous (27) A-RLP. Horses with septic synovitis had a lower survival rate (53.43%) than did horses with lacerations (91.89%). Within group 2, no significant differences in short- or long-term outcomes were found between horses with extrasynovial and fresh, minimally contaminated intrasynovial lacerations. For the horses returning to previous use, 80% of horses with septic synovitis and 72.72% of horses with lacerations were performing at the same or higher level at the time of follow-up. Conclusions and Clinical Relevance—The results of the present study indicated that A-RLP is a safe technique with minimal adverse effects. The IV route presented fewer complications than intraosseous injection. Horses with infection of synovial structures had a lower survival rate than did those with acute, minimally contaminated intrasynovial lacerations. The latter had a similar prognosis for horses with extrasynovial lacerations treated with A-RLP.

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Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate

Abstract: Topical application of 1% diclofenac sodium liposomal cream to sites of IVRLP in healthy horses decreased inflammation as judged by visual assessment and ultrasonography. Decreased inflammation may allow extended use of IVRLP and may result in a reduction in pain in treated horses.

Cited by 39 publications

References 10 publications

Influence of intravenous regional limb perfusion with amikacin sulfate onStaphylococcus aureusbioburden in distal limb wounds in horses

Influence of intravenous regional limb perfusion with amikacin sulfate onStaphylococcus aureusbioburden in distal limb wounds in horses

Morphine Synovial Fluid Concentrations After Intravenous Regional Limb Perfusion in Standing Horses

Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

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