Effect of Tocopherol-monoglucoside (TMG), a Water-soluble Glycosylated Derivate of Vitamin E, on Hematopoietic Recovery in Irradiated Mice

Abstract

A preparation of alpha-tocopherol monoglucoside (TMG) administered i.p. at a dose of 600 mg/kg immediately after whole body gamma irradiation was examined for its radioprotective efficacy towards bone marrow and peripheral blood nucleated cells. When mice received X-rays at a dose of 5,6 Gy, a marked decrease in bone marrow karyocytes and a reduction of peripheral leukocytes within the early post-irradiated period were observed. However these changes were attenuated in TMG-treated mice. Significant protection of blood lymphocytes was found for the TMG group of mice. The return to normal value of the reduced blood leukocyte count starting from the 8th day was more rapid in TMG-treated mice than in untreated irradiated mice. TMG administration was found to enhance hematopoietic recovery, as measured by the exceeded nucleated bone marrow cell count due to elevated amount of both lymphoid and granulocytic elements in the TMG-group, in comparison with that of both control irradiated and non-irradiated animals. These findings indicate that the radioprotective effect of TMG is apparently realized through its influence on hematopoietic system.

Mechanism of radioprotection by δ-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways

“…Previous studies have shown that treatment with vitamin E increased the number of colony forming units of erythroid precursors (CFU-E), enhanced erythropoiesis and haemoglobin levels, and corrected experimentally induced anaemia in laboratory animals [20][21][22]. Our data indicate that the stimulatory effect of DT3 is not limited to erythropoiesis, but extends to leukopoiesis and megakaryopoiesis.…”

Cytoprotective Effect of Podophyllum hexandrum Against Gamma Radiation is Mediated via Hemopoietic System Stimulation and Up-Regulation of Heme-oxygenase-1 and the Prosurvival Multidomain Protein Bcl-2

“…After the 7th day, recovery in the leukocyte count was observed, which can be attributed to the free radical scavenging property and DNA protective ability of aryltetralin lignans and flavonoids, due to which cells were able to repair the damage induced by radiation at bone marrow level. Similarly, protection of the hemopoietic system has been reported by using tocopherol monoglucoside 18 and phytoextracts such as Adhatoda vasica, Hippophae rhamnoides, Aegle marmelos, and Syzygium cumini. 19,20 The pattern of DLC in terms of neutrophils remained unchanged for the control group.…”

Tocopherol succinate: A promising radiation countermeasure

“…It forms a phenoxyl radical similar to trolox upon reaction with various one-electron oxidants. TMG protected mice against TBI, protected DNA strand breaks and thymine glycol formation induced by γ-irradiation [29,30], reduced the percentage of aberrant metaphase and the number of micronucleated erythrocytes [31], and enhanced hematopoietic recovery in irradiated mice [32].…”