Tocopherol succinate: A promising radiation countermeasure

Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor

“…All tested agents (DT3, GT3, and TS) are radioprotectors, and their radioprotective efficacy are comparable (Satyamitra et al, 2011;Singh et al, 2009Singh et al, , 2010Li et al, 2010;Ghosh et al, 2009). These agents are optimally effective when administered in a single dose at 24 h prior to radiation exposure.…”

“…This may not be the optimal time point for cytokine induction for all drugs. We decided to measure cytokines 24 h after drug injection since these drugs are most effective when administered 24 h prior to radiation exposure (Satyamitra et al, 2011;Singh et al, 2009Singh et al, , 2010Li et al, 2010;Ghosh et al, 2009). We were interested to know the levels of various cytokines in mice treated with these tocols at the time of radiation exposure.…”

“…During the last decade, tocotrienol research has gained substantial momentum. For radioprotective efficacy, tocopherol succinate (TS), delta tocotrienol (DT3), and gamma-tocotrienol (GT3) are comparable and appear better than other tocols (Satyamitra et al, 2011;Singh et al, 2009Singh et al, , 2012bLi et al, 2010). DT3 has been shown to have both radioprotective (administered before radiation exposure) and radiomitigative (administered after radiation exposure) efficacy (Satyamitra et al, 2011).…”

Progenitor Cells as a Bridging Therapy for Radiation Casualties

“…In addition, it is by far the most bioactive form based on the rat fetal resorption test, which is the classical assay for vitamins. Recently, the authors investigated the radioprotective efficacy of a-tocopherol succinate (TS) and their results indicate that TS is effective in protecting mice when given 24 h before irradiation 53 (dose reduction factor 1.28). TS also modulates the expression of various antioxidant genes and helps in hematopoietic recovery 54 .…”

“…TS also modulates the expression of various antioxidant genes and helps in hematopoietic recovery 54 . The authors demonstrated that TS stimulates G-CSF production and showed that TS-mediated protection can be neutralised by administration of G-CSF antibody 53,55,56 . The authors hypothesised that TS mobilises progenitor cells into the peripheral circulation.…”