Effect of tocilizumab and thymalin on systemic inflammation in patients with COVID-19

Кузник, Б. И.; Khavinson, V. Kh.; Lukyanov, S. A.; Шаповалов, К.Г.; Smolyakov, Yu. N.; Tereshkov, P.P.; Shapovalov, Yu. K.; Konnov, V.A.; Зайцев, Д. Н.; Magen, Eli

doi:10.29296/25877305-2020-11-17

Cited by 3 publications

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“…Penetrating into the blood vessels, SARS-CoV-2 spreads throughout the body. At the same time, the virus stimulates the endothelium and elements of the blood, causing a significant release of cytokines and chemokines, which in severe cases leads to a cytokine storm (Kuznik et al, 2020a(Kuznik et al, , 2020bKhavinson et al, 2020Khavinson et al, , 2021. It is assumed that there is an association between mast cell activation syndrome and the intensity of the cytokine storm in patients with long COVID-19.…”

Section: Pathogenesis Of Long Covid-19mentioning

confidence: 99%

Changes in the State of Vital Systems with Long COVID-19

2023

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— Long COVID-19 is a chronic disease that continues to be studied. Data on epidemiology and the main symptoms typical for long COVID-19 are presented. Issues related to the pathogenesis of the disease are discussed. At the same time, special attention is paid to the inflammation process (including of the vascular wall endothelium), the state of the immune system (cytokine storm), the hemostasis system (the mechanism for the development of microangiopathy and thrombosis), and oxidative stress. During the analysis, a special place is given to central nervous system disorders (including organic brain damage) and disorders of cognitive functions. In addition, currently known complications from the cardiovascular system and respiratory organs are described. The treatment and rehabilitation of patients with long COVID-19 is not only a medical, but also a significant social problem.

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Section: Pathogenesis Of Long Covid-19mentioning

confidence: 99%

Changes in the State of Vital Systems with Long COVID-19

2023

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“…The potential threat of the possibility of the avian influenza virus breaking through the biological barrier is growing, which, according to virologists, is able to destroy three-quarters of the world's population [37,43]. As a rule, for such widespread pathogens of viral infections as HIV infection, hepatitis B, coronavirus infection, herpes simplex, and for all newly emerging ones, humanity does not have direct-acting antiviral drugs, a number of insufficiently studied posed questions arise in the problem of a new coronavirus infection, including: the ability to influence the increase in the resistance of the human body without the use of drugs, often with a dubious effect of the type of immunostimulating agents [44,45]; to introduce modern nutraceuticals as a manda-tory component of patient therapy, including targeted action (medicine should not be food, but food can become medicine) [46][47][48]; tactics of health authorities regarding compliance with the calendar of immunoprophylaxis of infectious diseases against the background of an ongoing pandemic [49,50].…”

Section: Medical Sciencesmentioning

confidence: 99%

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2023

EJNH

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The journal is based in 2005 Двухлетний импакт-фактор РИНЦ = 0,283 Пятилетний импакт-фактор РИНЦ = 0,114 Журнал ЕВРОПЕЙСКИЙ ЖУРНАЛ ЕСТЕСТВОЗНАНИЯ зарегистрирован Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций. Свидетельство ПИ № ФС 77-19917. EUROPEAN JOURNAL OF NATURAL HISTORY Журнал включен в Реферативный журнал и Базы данных ВИНИТИ. Сведения о журнале ежегодно публикуются в международной справочной системе по периодическим и продолжающимся изданиям «Ulrich's Periodicals directory» в целях информирования мировой научной общественности. Журнал представлен в ведущих библиотеках страны и является рецензируемым. Журнал представлен в НАУЧНОЙ ЭЛЕКТРОННОЙ БИБЛИОТЕКЕ (НЭБ)головном исполнителе проекта по созданию Российского индекса научного цитирования (РИНЦ) и имеет импакт-фактор Российского индекса научного цитирования (ИФ РИНЦ).

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Prognosis of immune state following basic therapy and thymalin treatment in patients with severe COVID-19 infection

Кузник

Smolyakov

Шаповалов

et al. 2022

Russian Journal of Immunology

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Significant changes in cellular and humoral immunity are observed in new coronavirus infection (COVID-19). The cytokine storm develops in cases of severe clinical course, being accompanied by significantly increased levels of pro-inflammatory cytokines, often associated with suppression of immune response. At the same time, the prediction of the immune status is an urgent task, thus allowing timely correction of current therapy. The aim of our research was to evaluate predictive capability for the immune system changes on the 6th day of COVID-19 disease when using standard therapy, or with addition of immunocorrector thymalin to the treatment regimen. A retrospective study was conducted in 87 patients with severe COVID-19. All patients were divided into 2 groups, i.e., (1) controls who received basic treatment; (2) basic treatment supplied with thymalin (10 mg, intramuscular injections daily for 5 days). Assessment of severity and clinical course of COVID-19, and basic treatment regimen for the patients corresponded to current version of the interim Guidelines from the Ministry of Health of the Russian Federation Prevention, diagnosis and treatment of a new coronavirus infection COVID-19. Laboratory studies included complete blood counts, immunogram parameters with the calculation of the ratio of certain types of leukocytes were performed on the 1st and 6th days of observation. Statistical evaluation was made using scripts of the specialized statistical analysis language R (http://cran.r-project.org) version 4.1.3. The blood parameters were evaluated using the binary classification method. The changes in parameters of cellular immunity were classified by means of ROC-analysis. We have found that the basic therapy of severely ill COVID-19 patients was not followed by recovery of immune status on the 6th day from the start of treatment. At marginal level, one can only suggest a probable prediction of increase in WBC and MON counts, a decrease in CD4+, NK and CD8+perNK, as well as the CD4+/CD8+ ratio. Addition of thymalin to the basic therapy is largely accompanied by the normalization of immunogram parameters. At the same time, it is possible to predict, with excellent rating, an increased number of T-LIM, including CD4+ and B-LIM, and, with good rating, an increase in the total numbers of LIM, as well as CD8+, HLA-CD3+DR+ and NK cells. The data obtained in severe cases of COVID-19 make it possible to predict changes in immune status, and, hence, the course of the disease, at a high degree of probability.

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Effect of tocilizumab and thymalin on systemic inflammation in patients with COVID-19

Cited by 3 publications

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Changes in the State of Vital Systems with Long COVID-19

Changes in the State of Vital Systems with Long COVID-19

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Prognosis of immune state following basic therapy and thymalin treatment in patients with severe COVID-19 infection

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