Effect of TiF4 varnish on microbiological changes and caries prevention: in situ and in vivo models

Alexandria, Adílis Kalina; Nassur, Camila; Nóbrega, Camila Costa da; Branco-de-Almeida, Luciana Salles; Santos, Kátia Regina Netto dos; Vieira, Alexandre R.; Neves, Aline de Almeida; Rosalen, Pedro Luiz; Valença, Ana Maria Gondim; Maia, Lucianne Cople

doi:10.1007/s00784-018-2681-x

Cited by 18 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results (2 nd paper), the tested null hypothesis was partially rejected. TiF4 varnish was not able to change the clinical appearance of the white spot lesions, however, it improved the amount of mineral gain resulting in significant reduction of enamel fluorescence loss after 18 months of study, in agreement with previously in vitro and in situ studies (MAGALHÃES et al, 2008;ATTIN, 2010;COMAR et al, 2012;ALEXANDRIA et al, 2019;DOS SANTOS et al, 2019). With respect to prevention of new caries lesions, TiF4 varnish also presented a significant higher percentage value of sound surfaces at the end of study compared to placebo.…”

Section: Discussionsupporting

confidence: 86%

“…The protective effect of titanium tetrafluoride on dental caries has been intensively investigated under in vitro and in situ models (MAGALHÃES et al, 2008;COMAR et al, 2012;COMAR et al, 2017;SOUZA et al, 2018a;ALEXANDRIA et al, 2019;DOS SANTOS et al, 2019). Comar et al (2017) recently demonstrated a better effect of TiF4 varnish in remineralizing initial enamel caries lesions in situ, regardless of the caries activity (ranging from low to high), compared to NaF varnish, which was only able to remineralize enamel lesions under low cariogenic challenges.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months

Souza¹

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effect of TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months

Souza¹

View full text Add to dashboard Cite

“…From Alexandria et al . (2019) – ‘In the in vivo study, we observed that all rats gained weight and remained apparently active and healthy until the end of the experiment; no statistically significant difference was observed for weight gain among the groups (data not shown). The data was normally distributed’.…”

Section: Introductionmentioning

confidence: 89%

PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration

et al. 2021

View full text Add to dashboard Cite

Laws and ethics require that before conducting human clinical trials, a new material, device or drug may have to undergo testing in animals in order to minimize health risks to humans, unless suitable supporting grandfather data already exist. The Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) 2021 guidelines were developed exclusively for the specialty of Endodontology by integrating and adapting the ARRIVE (Animals in Research: Reporting In Vivo Experiments) guidelines and the Clinical and Laboratory Images in Publications (CLIP) principles using a validated consensus‐based methodology. Implementation of the PRIASE 2021 guidelines will reduce potential sources of bias and thus improve the quality, accuracy, reproducibility, completeness and transparency of reports describing animal studies in Endodontology. The PRIASE 2021 guidelines consist of a checklist with 11 domains and 43 individual items and a flowchart. The aim of the current document is to provide an explanation for each item in the PRIASE 2021 checklist and flowchart and is supplemented with examples from the literature in order for readers to understand their significance and to provide usage guidance. A link to the PRIASE 2021 explanation and elaboration document and PRIASE 2021 checklist and flowchart is available on the Preferred Reporting Items for study Designs in Endodontology (PRIDE) website (http://pride-endodonticguidelines.org/priase/).

show abstract

“…However, there is no innocuous method available for detecting invisible carious lesions before characteristic white spots become visible. Preventative measures such as photodynamic control of cariogenic bacteria [73], F-varnish [74], and particularly remineralization are more effective for managing shallow lesions (<20μm) [75]. A lack of proven technology to detect and assess early carious lesions (say <100μm) in enamel is a major deficit in clinical practice because caries intervention and remineralization technology should only be used when indicated.…”

Section: Incipient Lesionsmentioning

confidence: 99%

Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection

Roberts

Mangum

Schneider

2022

Curr Osteoporos Rep

View full text Add to dashboard Cite

Purpose of Review Compare noninfectious (part I) to infectious (part II) demineralization of bones and teeth. Evaluate similarities and differences in the expression of hard tissue degradation for the two most common chronic demineralization diseases: osteoporosis and dental caries. Recent Findings The physiology of demineralization is similar for the sterile skeleton compared to the septic dentition. Superimposing the pathologic variable of infection reveals a unique pathophysiology for dental caries. Summary Mineralized tissues are compromised by microdamage, demineralization, and infection. Osseous tissues remodel (turnover) to maintain structural integrity, but the heavily loaded dentition does not turnover so it is ultimately at risk of collapse. A carious tooth is a potential vector for periapical infection that may be life-threatening. Insipient caries is initiated as a subsurface decalcification in enamel that is not detectable until a depth of ~400μm when it becomes visible as a white spot. Reliable detection and remineralization of invisible caries would advance cost-effective wellness worldwide.

show abstract

Effect of TiF4 varnish on microbiological changes and caries prevention: in situ and in vivo models

Cited by 18 publications

References 31 publications

Effect of TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months

Effect of TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months

PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration

Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection

Contact Info

Product

Resources

About