Effect of Thyroid Hormone on Body Composition in Myxedema and Obesity

Kyle, Laurence H.; Ball, Megan; Doolan, Paul D.

doi:10.1097/00043764-196703000-00031

Cited by 9 publications

(10 citation statements)

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“…In thyrotoxicosis, muscle wasting is rather common and urinary excretion of urea nitrogen is increased (Boothby and Sandiford 1923; Kyle et al 1966). Boothby and Sandiford (1923) reported that food intake of about 74 kcal per kg of ideal body weight is necessary to keep nitrogen balance.…”

Section: Discussionmentioning

confidence: 99%

“…In thyrotoxicosis, gluconeogenesis from glycerol, lactate and amino acids is enhanced (Svednry 1966;Freedland and Krebs 1967;Sestoft et al 1977;Singh and Snyder 1978;Sato et al 1980), the content of glycogen in the liver is markedly reduced (Kuriyama 1918), and the nitrogen balance may easily shift to negative (Boothby and Sandiford 1923; Kyle et al 1966). These results suggest that the subjects with hyperthyroidism may easily fall in a state of relative starvation.…”

mentioning

confidence: 99%

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Carbohydrate metabolism in thyrotoxicosis, with special reference to its relation to calorie intake.

Sato

Saito

Kokubun

et al. 1982

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Carbohydrate metabolism in thyrotoxicosis, with special reference to its relation to calorie intake.

Sato

Saito

Kokubun

et al. 1982

Tohoku J. Exp. Med.

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“…In keeping with this, body weight was not affected when haloperidol was administered orally to male rats for three or six weeks (Minet-Ringuet et al, 2005; Pouzet et al, 2003), and was even suppressed under the longer treatment period of 80 weeks (Yoshida et al, 1995 51(7--8): 1129--1136, 2006 adipose tissue under the influence of hormonal changes such as increased serum levels of insulin (Cusin et al, 1990), corticosterone (Guillaume-Gentil et al, 1993) and growth hormone (Ho et al, 1996) and reduced serum levels of thyroid hormones (Kyle et al, 1966), IGF-1 (Shaw et al, 2003), and testosterone (Mudali and Dobs, 2004). However, our data show that not only does chronic haloperidol administration to male rats have no effect on body weight or food intake, it also has no effect on adiposity or the serum levels of many of the hormones that modulate body composition.…”

Section: Effect Of Haloperidol or Risperidone On Body Tissue Compositionmentioning

confidence: 99%

Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats

et al. 2006

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Antipsychotic drugs have been used effectively for the treatment of schizophrenia symptoms, but they are often associated with metabolic side effects such as weight gain and endocrine disruptions. To investigate the possible mechanisms of antipsychotic-induced metabolic effects, we studied the impact of chronic administration of a typical antipsychotic drug (haloperidol) and an atypical antipsychotic (risperidone) to male rats on food intake, body weight, adiposity, and the circulating concentrations of hormones and metabolites that can influence energy homeostasis. Chronic (28 days) haloperidol administration had no effect on food intake, weight gain or adiposity in male rats, whereas risperidone treatment resulted in a transient reduction in food intake and significantly reduced body weight gain compared to vehicle-treated control rats. Whereas neither antipsychotic had any effect on serum lipid profiles, glucose tolerance or the circulating concentrations of hormones controlled by the hypothalamo-pituitary-thyroid (free T4), -adrenal (corticosterone), -somatotropic (IGF-1), orgonadotropic axes (testosterone), haloperidol increased circulating insulin levels and risperidone increased serum glucagon levels. This finding suggests that haloperidol or risperidone induce distinct metabolic effects. Since metabolic disorders such as obesity and type 2 diabetes mellitus represent serious health issues, understanding antipsychotic-induced endocrine and metabolic effects may ultimately allow better control of these side effects.

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“…thyrotoxicosis; gluconeogenesis; glycerol; alanine In thyrotoxicosis, oxidation and removal of glucose are increased (Lamberg 1965), and muscle wasting is common with increased excretion of urinary nitrogen (Boothby and Sandiford 1923; Kyle et al 1966). Cori-cycle is enhanced and gluconeogenesis from glycerol is also increased in thyrotoxicosis (Svednry 1966;Freedland and Krebs 1967), but enhancement of gluconeogenesis from amino acids has not been proved (Freedland and Krebs 1967).…”

mentioning

confidence: 99%