Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population

Kumru, Pınar; Erdoğdu, Emre; Arısoy, Resul; Demirci, Oya; Ozkoral, Aysen; Ardıç, Cem; Ertekin, Arif Aktug; Erdoğan, Sinan; Özdemir, Nilüfer

doi:10.1007/s00404-014-3533-9

Cited by 70 publications

(60 citation statements)

References 24 publications

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“…In the study by Sharmeen et al there was a positive association which was similar to another study by Nazarpour et al in Iran. 5,8 Increased association was also found in the study by Mannisto et al between hypothyroidism in pregnancy and preeclampsia as well by Goel et al 2,3 No association with hypertensive disorders were found by Medici et al as well as by Kumru et al 7,9 Similar results were reported in the study by Gudovic et al 6 In this study there was no increased association for the development of hypertension in the case and control groups.…”

Section: Discussionsupporting

confidence: 87%

“…5 In another study by Mannisto et al it was observed that hypothyroid pregnant women have increased odds for developing this complication. 2 Hypothyroidism in pregnancy was more frequently associated with gestational diabetes in a study by Gudovic et al whereas no association was found in another study conducted in Turkey by Kumru et al 6,7 In the present study there was a statistically significant number of gestational diabetes in the case group compared to controls (p=0.00001).…”

Section: Discussioncontrasting

confidence: 51%

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Outcome of clinical hypothyroidism in pregnancy: a case control study

Lopamudra

Reddi

Ghose

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThyroid gland dysfunctions in the form of hypo or hyperthyroidism have been known to have a deleterious effect on fertility as well as pregnancy. The various hypofunction thyroid disorders encountered in pregnant women are clinical or clinical and subclinical hypothyroidism. Pregnancy itself modifies thyroid gland functions in the form of 50% increase in thyroxine (T4) and triiodothyronine (T3) production, decreased levels of thyrotropin (TSH) due to effect of human chorionic gonadotropin and 50% increase in daily iodine requirement.1 Clinical hypothyroidism is defined as decreased free thyroxine levels with an increased value of thyrotropin (>2.5miu/L). This has been associated with increased incidence of gestational hypertension and diabetes, preterm delivery and Caesarean section in pregnant women.2 This study is undertaken to find out the effects of adequately treated clinical hypothyroidism in pregnancy when compared with pregnant euthyroid controls. METHODSThis study was conducted in a tertiary care centre over a period of one year and 144 cases of clinical hypothyroidism in pregnancy were taken into account who formed the case group. Inclusion criteriaNewly diagnosed clinical hypothyroidism in pregnancy, TSH>2.5 mIU/L in 1 st and 3mIU/L in the 2 nd and 3 rd trimesters respectively according to American thyroid association guidelines. ABSTRACTBackground: Hypothyroidism in pregnancy is generally associated with various adverse outcomes. Also worldwide, there is an increased awareness about morbidity caused by this endocrinological disorder in pregnancy .This study is undertaken to evaluate the outcome of this condition in pregnancy. Methods: 144 newly diagnosed clinical hypothyroid pregnant women were taken as the case group and 145 age and parity matched euthyroid pregnant women were taken as controls. The outcome compared in between these two groups were pregnancy complications like gestational diabetes and hypertension , oligohydramnios, intrauterine growth restriction , intrauterine demise, Caesarean section rates and it's indication as well as neonatal outcome like birth weight and need for neonatal intensive care.Results: Clinical hypothyroidism in pregnancy constituted 6.1% of the total number of deliveries. There was a significantly higher number of gestational diabetes in the case group (p=0.0001). Caesarean sections done for the indication of foetal distress was significantly higher when compared with the control group (p=0.00002). Large for gestational age babies were more common in case group. Conclusions: Clinical hypothyroidism in pregnancy even when treated adequately might lead to complications.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 51%

Outcome of clinical hypothyroidism in pregnancy: a case control study

Lopamudra

Reddi

Ghose

2016

Int J Reprod Contracept Obstet Gynecol

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“…Kumru et al reported higher incidence of low birth weight in mothers with clinical hypothyroidism. 9 Nazarpour et al has also reported higher incidence of low birth weight in mothers with clinical hypothyroidism. 10 Study done by Goel P et al to know the maternal and perinatal outcome in pregnancy with hypothyroidism showed that prevalence of LBW was 13.3%.…”

Section: Discussionmentioning

confidence: 94%

“…9,10 In a study conducted by Hirsch et al premature deliveries were found out to be 2.9% in clinical hypothyroid. 11 The prevalence of low birth weight babies (birth weight less than 2.5 kg) in group A is found to be 10%.…”

Section: Discussionmentioning

confidence: 96%

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To study the neonatal outcomes in pregnancies with hypothyroidism in a tertiary referral centre

Faisal

Tibrewala

Afreen

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe

Sagrillo-Fagundes¹,

Bienvenue-Pariseault²,

Legembre

et al. 2019

Birth Defects Research

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The prototype death receptor CD95 (Fas) and its ligand, CD95L (FasL), have been thoroughly studied due to their role in immune homeostasis and elimination of infected and transformed cells. The fact that CD95 is present in female reproductive cells and modulated during embryogenesis and pregnancy has raised interest in its role in immune tolerance to the fetoplacental unit. CD95 has been shown to be critical for proper embryonic formation and survival. Moreover, altered expression of CD95 or its ligand causes autoimmunity and has also been directly involved in recurrent pregnancy losses and pregnancy disorders. The objective of this review is to summarize studies that evaluate the mechanisms involved in the activation of CD95 to provide an updated global view of its effect on the regulation of the maternal immune system. Modulation of the CD95 system components may be the immune basis of several common pregnancy disorders.

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Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population

Abstract: Pregnant women with anti-TPO antibody positivity alone or with subclinic hypothyroidism were more likely to experience a spontaneous preterm delivery.

Cited by 70 publications

References 24 publications

Outcome of clinical hypothyroidism in pregnancy: a case control study

Outcome of clinical hypothyroidism in pregnancy: a case control study

To study the neonatal outcomes in pregnancies with hypothyroidism in a tertiary referral centre

An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe

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