Effect of thyroid deficiency on oxidative phosphorylation in rat liver, kidney, and brain mitochondria

Katyare, Surendra S.; Joshi, Manasi; Fatterpaker, P.; Sreenivasan, A.

doi:10.1016/0003-9861(77)90294-6

Cited by 75 publications

(33 citation statements)

References 34 publications

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“…It is also well documented that the rates of substrate oxidation are significantly high in cardiac mitochondria (28)(29)(30)(31). This is consistent with the higher energy demand of the cardiac tissue (27,32).…”

Section: Introductionsupporting

confidence: 71%

“…Also, insulin treatment resulted in differential hyper-stimulation of respiratory activity in cardiac mitochondria from the male and female rats (28). Since the effects of diabetes and insulin treatment were differential in the male and female rats, and the incidence of CVDs is reported to be higher in the diabetic females (5,6,11,31) it was of interest to find out if the cardiac ROS metabolism is differentially affected in a sex-dependant manner.…”

Section: Introductionmentioning

confidence: 99%

“…Earlier, we have shown that streptozotocin-diabetes differentially affected oxidative energy metabolism in heart mitochondria from male and female rats (28). Also, insulin treatment resulted in differential hyper-stimulation of respiratory activity in cardiac mitochondria from the male and female rats (28).…”

Section: Introductionmentioning

confidence: 99%

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Diabetic cardiomyopathy and reactive oxygen species (ROS) related parameters in male and female rats: A comparative study

Akhileshwar

Patel

Katyare

2007

Indian J Clin Biochem

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Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Diabetic cardiomyopathy and reactive oxygen species (ROS) related parameters in male and female rats: A comparative study

Akhileshwar

Patel

Katyare

2007

Indian J Clin Biochem

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“…The increased expression of mitochondrial cytochrome oxidase subunit I in the tadpole may be correlated with changes in brain oxidative phosphorylation. In mammals, neonatal hypothyroidism results in decreased brain oxidative phosphorylation (73) and alterations in mitochondrial morphology (74). Recent reports in rat and mouse show that the expression of several mitochondrial genes is altered by thyroid status in neonatal animals (53,54,75).…”

Section: Identification Of T 3 -Regulated Neuralmentioning

confidence: 99%

Thyroid Hormone-dependent Gene Expression Program for Xenopus Neural Development

Denver

Pavgi

Shi

1997

Journal of Biological Chemistry

126

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Although thyroid hormone (TH) plays a significant role in vertebrate neural development, the molecular basis of TH action on the brain is poorly understood. Using polymerase chain reaction-based subtractive hybridization we isolated 34 cDNAs for TH-regulated genes in the diencephalon of Xenopus tadpoles. Northern blots verified that the mRNAs are regulated by TH and are expressed during metamorphosis. Kinetic analyses showed that most of the genes are up-regulated by TH within 4 -8 h and 13 are regulated by TH only in the brain. All cDNA fragments were sequenced and the identities of seven were determined through homology with known genes; an additional five TH-regulated genes were identified by hybridization with known cDNA clones. These include five transcription factors (including two members of the steroid receptor superfamily), a TH-converting deiodinase, two metabolic enzymes, a protein disulfide isomerase-like protein that may bind TH, a neural-specific cytoskeletal protein, and two hypophysiotropic neuropeptides. This is the first successful attempt to isolate a large number of TH-target genes in the developing vertebrate brain. The gene identities allow predictions about the gene regulatory networks underlying TH action on the brain, and the cloned cDNAs provide tools for understanding the basic molecular mechanisms underlying neural cell differentiation.

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“…The O î generation leads to an increase in the production of H2O2 which, in turn, can generate highly reactive hydroxyl radicals. An alteration in the thyroid state has considerable effects on the respirato ry activities of rat liver mitochondria, thy roidectomy reducing [ 10] and triiodothyron ine administration to hypothyroid animals in creasing [11] such activities. It has been sug gested that the thyroid hormone-induced in crease in mitochondrial respiratory activities leads to accelerated free radical production and to changes in the antioxidant defense sys tems [12], The mitochondrial population is, however, heterogeneous with regard to its characteristics which can be greatly altered according to the thyroid state.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thyroid State on Characteristics Determining the Susceptibility to Oxidative Stress of Mitochondrial Fractions from Rat Liver

Venditti¹,

Meo²,

Leo³

1996

Cell Physiol Biochem

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We have studied biochemical and functional characteristics of three mitochondrial fractions resolved by differential centrifugation from the liver of rats in different thyroid states. In particular, the relation between cytochrome and antioxidant content of the mitochondria and their oxygen consumption and response to oxidative stress has been investigated. The cytochrome content is greater in the fractions at higher density, whereas the opposite pattern is shown for antioxidant level. These biochemical characteristics seem to determine functional ones. In fact, the fraction at higher density exhibit greater oxygen consumption and smaller capacity for opposing a oxidative stress. A similar dependence of functional characteristics on biochemical ones was found in altered thyroid states. Hypothyroidism is associated with decreased cytochrome content and oxygen consumption and increased antioxidant level and effectiveness in responding to oxidative stress. The treatment of thyroidectomized rats with triiodothyronine leads to reversion of such a pattern. We are inclined to explain the differences in susceptibility to oxidative stress of the mitochondria by a modulation exerted by thyroid hormone, during the normal maturation process, on their cytochrome content. In effect, such a content is able to determine both respiratory characteristics and sensitivity to pro-oxidants of mitochondria. This sensitivity and the decrease of antioxidants, possibly due to free radical production associated with the increased oxygen flux, make the mitochondria less able to respond to an oxidative challenge.

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Effect of thyroid deficiency on oxidative phosphorylation in rat liver, kidney, and brain mitochondria

Cited by 75 publications

References 34 publications

Diabetic cardiomyopathy and reactive oxygen species (ROS) related parameters in male and female rats: A comparative study

Diabetic cardiomyopathy and reactive oxygen species (ROS) related parameters in male and female rats: A comparative study

Thyroid Hormone-dependent Gene Expression Program for Xenopus Neural Development

Effect of Thyroid State on Characteristics Determining the Susceptibility to Oxidative Stress of Mitochondrial Fractions from Rat Liver

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